Arctigenin

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Arctigenin

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Cat No: 14913

Biochemicals - Kinase Inhibitors

Arctigenin is an extract from A. lappa, a burdock plant traditionally used in Japanese Kampo medicine for its antioxidant, anti-inflammatory, antiproliferative, and antiviral activity. At 0.1 μM, arctigenin can block the activation of Akt induced by g...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone

Correlated keywords:

26687-78-5 41328-87-4 natural products an extracts from Arctium lappa A. antioxidants anti oxidants anti-oxidants inflammatory antiiflammatory anti-proliferative proliferative anti-viral viral anti-inflammatory antiproliferative antiviral pancreatic cancers in?uenza A virus neuroprotective Japanese encephalitis burdock plants medicines PANC-1 PANC1 PANCs 1 one glucose starvation kampo therapeutic cerebral artery occluded ischemic strokes

Product Overview:
Arctigenin is an extract from A. lappa, a burdock plant traditionally used in Japanese Kampo medicine for its antioxidant, anti-inflammatory, antiproliferative, and antiviral activity. At 0.1 μM, arctigenin can block the activation of Akt induced by glucose starvation in pancreatic cancer PANC-1 cells, which is a key process in the tolerance exhibited by cancer cells to glucose starvation.{23767} It has potent in vitro antiviral activities against inﬂuenza A virus and shows neuroprotective effects against an experimental mouse model of Japanese encephalitis.{23769,23766} Arctigenin also demonstrates a therapeutic effect in ischemic stroke treatment of middle cerebral artery occluded rats by suppressing microglia activation and decreasing IL-1β and TNF-α expression.{23768}

Size	10 mg
Shipping	dry ice
CAS Number	7770-78-7
Molecular Formula	C₂₁H₂₄O₆
SMILES	COC1=C(O)C=CC(C[C@H]([C@@H](CC2=CC(OC)=C(OC)C=C2)CO3)C3=O)=C1
Molecular Weight	372,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2912.49
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.