NSC 87877

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NSC 87877

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Cat No: 14908

Biochemicals - Small Molecule Inhibitors

The Src homology region 2 domain-containing phosphatases (SHP) known as SHP-1 and SHP-2 act downstream of receptor and non-receptor tyrosine kinase to modulate signal transduction.{23672} NSC 87877 is a cell-permeable, inhibitor of both SHP-1 and SHP-2...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

8-hydroxy-7-[2-(6-sulfo-2-naphthalenyl)diazenyl]-5-quinolinesulfonic acid

Correlated keywords:

inhibitors inhibits inhibitions phosphatases signals transductions Src homology regions 2 SH2 SH-2 SHs 2 two domain-containing domains containing phosphatases SHPs SHP1 SHP2 one two 1 2 SHP-1 SHP-2 NSC87877 NSCs 87877 NSC-87877 cells permeable potent DUSP26 DUSP-26 DUSP 26 dual-specificity phosphatase ERk1/2 ERK ½ ERK-1/2 HEK293 HEK-293 HEKs 293 extracellular signals regulated kinases humans embryonic kidneys epidermal growth factors proteins tyrosine Ras calcium thrombin platelets acetylcholine myotubes

Product Overview:
The Src homology region 2 domain-containing phosphatases (SHP) known as SHP-1 and SHP-2 act downstream of receptor and non-receptor tyrosine kinase to modulate signal transduction.{23672} NSC 87877 is a cell-permeable, inhibitor of both SHP-1 and SHP-2 (IC50 = 355 and 318 nM, respectively).{23672} It is much less effective against other protein tyrosine phosphatases and the dual-specificity phosphatase 26.{23672,23671} Through its effects on SHP-1 or SHP-2, NSC 87877 blocks epidermal growth factor receptor-induced activation of Ras and ERK1/2 in HEK293 cells, stimulates store-operated calcium entry in response to thrombin in platelets, and increased acetylcholine receptor clustering in myotubes.{23672,23669,23670}

Size	10 mg
Shipping	dry ice
CAS Number	56990-57-9
Molecular Formula	C₁₉H₁₃N₃O₇S₂
SMILES	OS(C(C=C1)=CC(C1=C2)=CC=C2/N=N/C3=C(O)C4=NC=CC=C4C(S(O)(=O)=O)=C3)(=O)=O
Molecular Weight	459,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.49
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.