Sulfaphenazole

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Sulfaphenazole

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Cat No: 14844

Biochemicals - Small Molecule Inhibitors

CYP2C9 is a major cytochrome P450 enzyme that is involved in the metabolic clearance of various therapeutic agents. Disruption of this enzyme’s activity can lead to adverse drug reactions.{24411} Sulfaphenazole is an inhibitor of CYP2C9 (Ki = 0.3 μM) t...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-amino-N-(1-phenyl-1H-pyrazol-5-yl)-benzenesulfonamide

Correlated keywords:

165121-67-5 CYP2C9 cytochromes P450 CYP450 enzymes drugs metabolism adverse reactions inhibitors inhibits inhibitions endothelium-derived endothelium derived hyperpolarizing factors synthase EDHF ROS vasodilation coronary diseases CYPs isoforms reactive oxygen species endothelial cells vascular tones homeostasis depocid depotsulfonamide eftolon firmazolo inamil isarol V merian microtan pirazolo orisul orisulf paidazolo plisulfan raziosulfa sulfabid sulfaphenazol sulfaphenazon sulfaphenylpyrazole

Product Overview:
CYP2C9 is a major cytochrome P450 enzyme that is involved in the metabolic clearance of various therapeutic agents. Disruption of this enzyme’s activity can lead to adverse drug reactions.{24411} Sulfaphenazole is an inhibitor of CYP2C9 (Ki = 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Kis = 63 and 29 μM for CYP2C8 and CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19).{24410,24408} At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.{24409}

Size	250 mg
Shipping	dry ice
CAS Number	526-08-9
Molecular Formula	C₁₅H₁₄N₄O₂S
SMILES	NC1=CC=C(S(NC2=CC=NN2C3=CC=CC=C3)(=O)=O)C=C1
Molecular Weight	314,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.