Confirm delete?

Bertin Bioreagent
logo
All categories
Contact Us
You are here :

Azaserine

  • Zoom
    Azaserine
  • Azaserine
Cat No: 14834
Biochemicals - Natural Products
Cayman

Azaserine is a tumor-inhibiting antibiotic isolated from a species of Streptomyces that functions as a glutamine analog.{23660,21899} At 25 μM, it inhibits the glutamine-dependent amidotransferases involved in nucleotide biosynthesis, phosphoribosylfo...

More

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • O-(2-diazoacetyl)-L-serine
Correlated keywords:
  • NSCs 742 NSC-742 NSC742 glutamines glutamine-dependent dependent amidotransferases inhibits inhibitions nucleotides biosynthesis anti-tumor anti-cancer antibiotic anti tumors cancers antitumors anticancers phosphoribosylformylglycinamidine synthetases N-formylglycineamidine ribotides synthetases FGAM glucosamine-6-phosphate isomerases GlcN-6-P hexosamines biosynthetics pathways UDP-N-acetylglucosamines UDP-GlcNAc O-linked glycoproteins antagonist active activity 438493-22-2 L-azaserine Ps 165 P-165 P165 CI-337 CIs 337 CI337 CNs 15757 CN-15757 CN15757 Streptomyces antioxidants hyperglycemic endothelial damages
Product Overview:
Azaserine is a tumor-inhibiting antibiotic isolated from a species of Streptomyces that functions as a glutamine analog.{23660,21899} At 25 μM, it inhibits the glutamine-dependent amidotransferases involved in nucleotide biosynthesis, phosphoribosylformylglycinamidine synthetase and glucosamine-6-phosphate isomerase.{21899,18311} Azaserine also inhibits the hexosamine biosynthetic pathway, which shunts excessive intracellular glucose into the biosynthesis of UDP-N-acetylglucosamine and the formation of O-linked glycoproteins.{23661} Azaserine has been shown to protect against hyperglycemic endothelial damage through its antioxidant effects.{23661}
Size 10 mg
Shipping dry ice
CAS Number 115-02-6
Molecular Formula C5H7N3O4
SMILES O=C(C=[N+]=[N-])OC[C@H](N)C(O)=O
Molecular Weight 173,1
Formulation A crystalline solid
Purity ≥98%
Custom Code 2922.19
UNSPSC code 12352100

Click here to ask for your quote and get 15% off Cayman's products.

 

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

/ We also advise you

Cross selling for this product : Azaserine There are 2 products.

Search