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BMS 345541 (trifluoroacetate salt)

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    BMS 345541 (trifluoro<wbr/>acetate salt)
  • BMS 345541 (trifluoro<wbr/>acetate salt)
Cat No: 16667
Biochemicals - Kinase Inhibitors
Cayman
€46.00
Price is excluding VAT and does not include packaging neither shipping

BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 µM).{27271} It is without effect against a panel of other serine/threonine and tyrosine kinases at 100 µM.{27271} BMS 345541 inhibits signaling through nuclea...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • N1-​(1,​8-​dimethylimidazo[1,​2-​a]​quinoxalin-​4-​yl)​-1,​2-​ethanediamine, trifluoroacetate salt
Correlated keywords:
  • biochemical NF-κB inflammation cancer signal transduction intracellular signaling gene regulation arthritis inhibitor inhibit 445430-58-0 547757-23-3 selective IKK-α IKK-β IKKα IKKβ III BMS345541 cell permeable IKB kinase nuclear factor-κB in vivo mice pharmacokinetic joint inflammation damage collagen-induce apoptosis melanoma vitro phosphorylation
Product Overview:
BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 µM).{27271} It is without effect against a panel of other serine/threonine and tyrosine kinases at 100 µM.{27271} BMS 345541 inhibits signaling through nuclear factor-κB (NF-κB) both in cells and in vivo, showing excellent pharmacokinetics in mice.{27271} It blocks joint inflammation and damage in collagen-induced arthritis in mice and induces apoptosis in melanoma cells both in vitro and in vivo.{27267,27270} BMS 345541 is used to explore novel roles for IKK phosphorylation and NF-κB signaling.{27268,27269}
Size 1 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
Molecular Formula C14H17N5 • 2CF3COOH
SMILES CC1=CN=C2N1C3=C(C=CC(C)=C3)N=C2NCCN.FC(F)(C(O)=O)F.FC(F)(C(O)=O)F
Molecular Weight 483,4
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.49
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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