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Tegaserod (maleate)

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    Tegaserod (maleate)
  • Tegaserod (maleate)
Cat No: 14692
Biochemicals - Receptor Pharmacology
Cayman

Tegaserod (maleate) is a potent agonist of the serotonin 4 receptor (5-HT4, Ki = 3.9-31 nM).{24432,24434} As 5-HT4 receptors are associated with cholinergic nerves lining the colon, tegaserod (maleate) stimulates colonic motility and transit in vivo, ...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 2-[(5-methoxy-1H-indol-3-yl)methylene]-N-pentyl-hydrazinecarboximidamide, 2Z-butenedioate
Correlated keywords:
  • receptors agonists antagonists neurosciences potent 5-HT4 5 HT4 HTs 5HT4 serotonin 4 four cholinergic nerves lining colon colonic motility in vivo gastrointestinal tracts HT2A HT2B HT2C 5-HT2A 5-HT2B 5-HT2C SDZ-HTF-919 SDZ HTF 919 HTF-919 SDZHTF919 SDZ-HTF tegaserod hydrogen tegibs 6 tegibs-6 zelmac zelnorm maleate stimulates transit in vivo healthy diseased selectivity antagonists 5-HT3 HT3 5- 5 HTF919 SDZ-HTF919 H
Product Overview:
Tegaserod (maleate) is a potent agonist of the serotonin 4 receptor (5-HT4, Ki = 3.9-31 nM).{24432,24434} As 5-HT4 receptors are associated with cholinergic nerves lining the colon, tegaserod (maleate) stimulates colonic motility and transit in vivo, in both healthy and diseased gastrointestinal tracts.{24430,24429} However, it lacks selectivity, since it also acts as an antagonist for the 5-HT2A, 5-HT2B, and 5-HT2C receptors (Ki = 32, 3.9, and 100 nM, respectively).{24435,24431,24429} It is a weak agonist of 5-HT3 (Ki ≤ 10 μM).{24433}
Size 5 mg
Shipping dry ice
CAS Number 189188-57-6
Molecular Formula C16H23N5O • C4H4O4
SMILES COC(C=C1)=CC2=C1NC=C2/C=N/NC(NCCCCC)=N.OC(/C=C\C(O)=O)=O
Molecular Weight 417,5
Formulation A crystalline solid
Purity ≥98%
Custom Code 2922.19
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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