Bumetanide

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Bumetanide

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Cat No: 14630

Biochemicals - Receptor Pharmacology

Bumetanide is an inhibitor of Na-K-2Cl cotransporter 1 (NKCC1; IC50 = 0.68 µM).{60442} It is selective for NKCC1 over NKCC2 (IC50 = 4 µM). Bumetanide is an agonist of G protein-coupled receptor 35 (GPR35; EC50 = 10 µM).{60443} It also inhibits various...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-benzoic acid

Correlated keywords:

Bufenox Bumethanide Bumex Burinex Edemex Fontego Fordiuran Lixil Lunetoron PF1593 Ro-106338 Ro106338 NKCC-1 2 Na-K2Cl NaK-2Cl NaK2Cl GPR-35

Product Overview:
Bumetanide is an inhibitor of Na-K-2Cl cotransporter 1 (NKCC1; IC50 = 0.68 µM).{60442} It is selective for NKCC1 over NKCC2 (IC50 = 4 µM). Bumetanide is an agonist of G protein-coupled receptor 35 (GPR35; EC50 = 10 µM).{60443} It also inhibits various carbonic anhydrases.{23242} Bumetanide (0.1 mg/kg) increases urine flow and sodium and potassium excretion, as well as decreases sodium reabsorption, in anesthetized dogs.{60444} It reduces brain edema and infarct size in a rat model of stroke induced by permanent middle cerebral artery occlusion (MCAO) when administered at doses ranging from 7.6 to 30.4 mg/kg.{60445} Formulations containing bumetanide have been used in the treatment of edema associated with congestive heart failure and hepatic and renal diseases.

Size	500 mg
Shipping	dry ice
CAS Number	28395-03-1
Molecular Formula	C₁₇H₂₀N₂O₅S
SMILES	CCCCNC1=C(OC2=CC=CC=C2)C(S(N)(=O)=O)=CC(C(O)=O)=C1
Molecular Weight	364,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.