1-EBIO

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1-EBIO

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Cat No: 14575

Biochemicals - Ion Channel Modulation

1-EBIO is an activator of Ca2+-sensitive K+ channels (EC50 = 490 µM in T84 human carcinoma cells).{23032} This action is sensitive to the neurotoxin charybdotoxin (Ki = 3.5 nM). In mouse colonic epithelia, 1-EBIO also activates cAMP-sensitive K+ chann...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-ethyl-1,3-dihydro-2H-benzimidazol-2-one

Correlated keywords:

ions channels/pumps channels pumps agonists activators KCa 1EBIO EBIO 1 ethylbenzimidazolinones Ca2+ sensitive K+ potassium calcium T84 carcinoma cells cAMPs 293B epithelium Cl- secretory currents conductance 1-ethylbenzimidazolin-2-one 3-ethyl-2-benzimidazolinone 1-ethyl-2-oxo-2,3-dihydrobenzimidazole, 1-ethyl-1,3-dihydrobenzimidazol-2-one 1-ethyl-2-benzimidazolinone humans neurotoxins charybdotoxins mouse colonic epithelia nasal activates intermediates diverse physiological functions

Product Overview:
1-EBIO is an activator of Ca2+-sensitive K+ channels (EC50 = 490 µM in T84 human carcinoma cells).{23032} This action is sensitive to the neurotoxin charybdotoxin (Ki = 3.5 nM). In mouse colonic epithelia, 1-EBIO also activates cAMP-sensitive K+ channels, a response this is inhibited by 293B.{23033} In this type of epithelium, but not mouse nasal epithelia, 1-EBIO activates both types of channels, resulting in large Cl- secretory currents.{23029} It also activates the human intermediate conductance Ca2+-activated K+ channel (EC50 = 74 µM).{23030} 1-EBIO is currently used to study the role of these types of K+ channels in diverse physiological functions.{23031,23028}

Size	5 mg
Shipping	dry ice
CAS Number	10045-45-1
Molecular Formula	C₉H₁₀N₂O
SMILES	O=C(N1CC)NC2=C1C=CC=C2
Molecular Weight	162,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.