PPADS (sodium salt)

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PPADS (sodium salt)

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Cat No: 14537

Biochemicals - Ion Channel Modulation

P2X and P2Y purinergic receptors are ATP-sensitive receptors responsible for mediating a large variety of excitatory postsynaptic responses including fast transmission at central synapses, contraction of smooth muscle cells, platelet aggregation, macro...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[2-[4-formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]diazenyl]-1,3-benzenedisulfonic acid, tetrasodium salt

Correlated keywords:

149017-66-3 P2 purinergic receptors antagonists P2X1 P2X2 P2X3 P2X5 ischemia ATP non-selectives non selectives nonselectives P-2 P 2 blocks recombinant P2X P2X1-5 P2Y4 P2Y P2Y P2Y-like antagonism cerebral artery occlusions MCAO middle hypertensives adenosines triphosphates mediates mediating excitatory effects postsynaptic responses fast transmissions central synapses contractions smooth muscles cells platelets aggregations macrophages activations apoptosis deaths blocking neuroprotective ischemia models middle rats

Product Overview:
P2X and P2Y purinergic receptors are ATP-sensitive receptors responsible for mediating a large variety of excitatory postsynaptic responses including fast transmission at central synapses, contraction of smooth muscle cells, platelet aggregation, macrophage activation, and apoptosis. PPADS is a non-selective P2 purinergic antagonist that blocks recombinant P2X1-5 (IC50s = 1-2.6 μM), native P2Y2-like (IC50 = ~0.9 mM), and recombinant P2Y4 (IC50 = ~15 mM) receptors.{22825} PPADS antagonism of ATP-sensitive P2 receptors produces neuroprotective effects in an ischemia model with permanent middle cerebral artery occlusion in spontaneously hypertensive rats.{22824}

Size	10 mg
Shipping	dry ice
CAS Number	192575-19-2
Molecular Formula	C₁₄H₁₀N₃O₁₂PS₂ • 4Na
SMILES	[H]C(C1=C(COP([O-])([O-])=O)C(/N=N/C2=C(S([O-])(=O)=O)C=C(S([O-])(=O)=O)C=C2)=NC(C)=C1O)=O.[Na+].[Na+].[Na+].[Na+]
Molecular Weight	599,3
Formulation	A solid
Purity	≥95%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.