Cilostamide

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Cilostamide

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Cat No: 14455

Biochemicals - Small Molecule Inhibitors

Cilostamide is a selective inhibitor of phosphodiesterase (PDE)3A and PDE3B with IC50 values of 27 and 50 nM, respectively.{19198} It is less selective for inhibition of PDE1, PDE2, PDE4, PDE5, and PDE7 (IC50s = 12 to > 300 μM).{19198} Cilostamide has...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-cyclohexyl-4-[(1,2-dihydro-2-oxo-6-quinolinyl)oxy]-N-methyl-butanamide

Correlated keywords:

anti-platelets inhibitors PDE3 antithrombic aggregations cAMPs anti platelets antiplatelets inhibits inhibitions PDE-3 PDEs 3 selectives phosphodiesterases PDE3A PDE3B thrombin-induced OPCs 3689 OPC3689 OPC-3689 cardiology cyclic nucleotides intracellular signaling PDE1 PDE2 PDE4 PDE5 PDE7 PDE3A PDE3B

Product Overview:
Cilostamide is a selective inhibitor of phosphodiesterase (PDE)3A and PDE3B with IC50 values of 27 and 50 nM, respectively.{19198} It is less selective for inhibition of PDE1, PDE2, PDE4, PDE5, and PDE7 (IC50s = 12 to > 300 μM).{19198} Cilostamide has been shown to inhibit thrombin-induced platelet aggregation with an IC50 value of 1.1 μM.{19198}

Size	5 mg
Shipping	dry ice
CAS Number	68550-75-4
Molecular Formula	C₂₀H₂₆N₂O₃
SMILES	CN(C(CCCOC1=CC=C(NC(C=C2)=O)C2=C1)=O)C3CCCCC3
Molecular Weight	342,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.