TBB - C6HBr4N3 - Bertin Bioreagent

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TBB

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Cat No: 14453

Biochemicals - Kinase Inhibitors

TBB is an ATP/GTP-competitive inhibitor of casein kinase 2 (CK2; IC50 = 0.15 µM for rat liver CK2).{22897} It also inhibits PIM3 and DYRK2 with IC50 values of 0.86 and 0.99 µM, respectively, and several other protein kinases with IC50 values in the lo...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4,5,6,7-tetrabromo-1H-benzotriazole

Correlated keywords:

inhibitors cancers tetrabromobenzotriazoles CK2 inhibits inhibitions casein kinases 2 CK-2 CKs 2 CCK2 CCK-2 CCKs 2 cyclin A GSK3b GSK3.beta. GSK3beta GSK3? phosphorylase enzymes

Product Overview:
TBB is an ATP/GTP-competitive inhibitor of casein kinase 2 (CK2; IC50 = 0.15 µM for rat liver CK2).{22897} It also inhibits PIM3 and DYRK2 with IC50 values of 0.86 and 0.99 µM, respectively, and several other protein kinases with IC50 values in the low micromolar range but displays less than 10% inhibition at 26 additional kinases up to 10 µM.{22896,22897}

Size	5 mg
Shipping	dry ice
CAS Number	17374-26-4
Molecular Formula	C₆HBr₄N₃
SMILES	BrC1=C2C(NN=N2)=C(Br)C(Br)=C1Br
Molecular Weight	434,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.