Confirm delete?

Bertin Bioreagent
logo
All categories
Contact Us
You are here :

Alsterpaullone

  • Zoom
    Alster<wbr/>paullone
  • Alster<wbr/>paullone
Cat No: 14428
Biochemicals - Kinase Inhibitors
Cayman

Alsterpaullone is a derivative of kenpaullone (Item No. 10010239), an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK3β). With slightly improved potency over kenpaullone, alsterpaullone ...

More

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 7,12-dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one
Correlated keywords:
  • 959569-16-5 proteins kinases inhibitors inhibits inhibitions cells cycles cancers NSC705701 NSC-705701 kenpaullone cyclins cyclin-dependent glycogens synthases 3 GSK3 Cdk1/cyclin B Cdk2/cyclin A Cdk2/cyclin E Cdk5/p25 GSK-3?/? Wnt signaling proliferatins paullones CDKs GSKs signals signalling Alzheimer's diseases expressions antitumors anti tumors anti-tumors apoptosis inducers induction ATP-competitive adenosines triphosphates cytosolics degradations ?-catenin b-catenin beta-catenin .beta.-catenin canonical pathways tau phosphorylations
Product Overview:
Alsterpaullone is a derivative of kenpaullone (Item No. 10010239), an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3β (GSK3β). With slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively.{22493,14995} Alsterpaullone has been used to inhibit the cytosolic degradation of β-catenin to alter the canonical Wnt signaling pathway in primary axis patterning, to reduce tau phosphorylation in an effort to modify neuropathological events associated with Alzheimer’s disease, and to alter cell proliferation or protein expression in various diseases.{22492,22495,22494}
Size 1 mg
Shipping dry ice
CAS Number 237430-03-4
Molecular Formula C16H11N3O3
SMILES O=C1CC2=C(NC3=C2C=C([N+]([O-])=O)C=C3)C4=CC=CC=C4N1
Molecular Weight 293,3
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.49
UNSPSC code 12352100

Click here to ask for your quote and get 15% off Cayman's products.

 

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

/ We also advise you

Cross selling for this product : Alster<wbr/>paullone There are 10 products.

Search