(S)-3,5-DHPG

Biochemicals - Receptor Pharmacology

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Cat No: 14411

Biochemicals - Receptor Pharmacology

(S)-3,5-DHPG, known more commonly as DHPG, is an agonist of the group I metabotropic glutamate receptors (mGluRs), binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 µM, respectively) but not ionotropic glutamate receptors.{23341} The (S)-enantiomer i...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(?S)-amino-3,5-dihydroxy-benzeneacetic acid

Correlated keywords:

receptors agonists signals transductions neurosciences DHPG groups I metabotropic glutamates mGLuRs mGluR1a mGluR5a enantiomers (S)-enantiomer neuronal signaling (S)-3,5-DHPG (S) 3 5 ionotropic potent (R)-enantiomer (R)

Product Overview:
(S)-3,5-DHPG, known more commonly as DHPG, is an agonist of the group I metabotropic glutamate receptors (mGluRs), binding both mGluR1a and mGluR5a (Ki = 0.9 and 3.9 µM, respectively) but not ionotropic glutamate receptors.{23341} The (S)-enantiomer is about ten times more potent than the (R)-enantiomer.{23342} (S)-3,5-DHPG is commonly used to evaluate the roles of group I mGluRs in neuronal signaling.{23339,23340}

Size	1 mg
Shipping	dry ice
CAS Number	162870-29-3
Molecular Formula	C₈H₉NO₄
SMILES	OC1=CC([C@H](N)C(O)=O)=CC(O)=C1
Molecular Weight	183,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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