2-deoxy-D-Glucose

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2-deoxy-D-Glucose

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Cat No: 14325

Biochemicals - Kinase Inhibitors

2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.{22664,61618} It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phospha...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-deoxy-D-arabino-hexose

Correlated keywords:

61-58-5 2092-72-0 3724-71-8 4825-30-3 7640-18-8 glucose analogs hexokinases inhibitors glycolysis hypoxia cancers neurodegeneration calories restriction aging ages non-metabolizable inhibits inhibitions phosphorylations ATP cells cycles deaths hypoxia autophagy ROS reatives oxygen species AMPK tumors growths grows Ba2758 Ba-2758 Bas 2758 NSC15193 NSCs 15193 NSC-15193 61-58-5 2-deoxyglucose D-glucose 2-deoxy-D-mannose 2-deoxy-D-glucose apoptosis adenosines triphosphates proteins glycosylations ER endoplasmic reticulums induces inducing folds folding responses in vitro models blocks blocking animals

Product Overview:
2-deoxy-D-Glucose is a glucose antimetabolite and an inhibitor of glycolysis.{22664,61618} It inhibits hexokinase, the enzyme that converts glucose to glucose-6-phosphate, as well as phosphoglucose isomerase, the enzyme that converts glucose-6-phosphate to fructose-6-phosphate.{22666} 2-deoxy-D-glucose (16 mM) induces apoptosis in SK-BR-3 cells, as well as inhibits the growth of 143B osteosarcoma cells cultured under hypoxic conditions when used at a concentration of 2 mg/ml.{61619,22663} In vivo, 2-deoxy-D-glucose (500 mg/kg) reduces tumor growth in 143B osteosarcoma and MV522 non-small cell lung cancer mouse xenograft models when used alone or in combination with doxorubicin (Item No. 15007) or paclitaxel (Item No. 10461).{61620}

Size	1 g
Shipping	dry ice
CAS Number	154-17-6
Molecular Formula	C₆H₁₂O₅
SMILES	O[C@@H]1[C@@H](CO)OC(O)C[C@H]1O
Molecular Weight	164,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.99
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.