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Benzamil (hydrochloride)

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    Benzamil (hydro<wbr/>chloride)
  • Benzamil (hydro<wbr/>chloride)
Cat No: 14313
Biochemicals - Ion Channel Modulation
Cayman

Benzamil is a derivative of amiloride (Item No. 14409).{48507} Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles. It is also an inh...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 3,5-diamino-6-chloro-N-[imino[(phenylmethyl)amino]methyl]-2-pyrazinecarboxamide, monohydrochloride
Correlated keywords:
  • 2898-76-2 polycystinL TRPP 3
Product Overview:
Benzamil is a derivative of amiloride (Item No. 14409).{48507} Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles. It is also an inhibitor of the Na+/Ca2+ exchanger (NCX) that inhibits the cytosolic calcium response to extracellular sodium depletion in mouse podocytes (IC50 = ~100 nM).{48508} Benzamil inhibits transient receptor potential polycystin-L (TRPP3; IC50 = 1.1 μM), a member of the TRP superfamily of cation channels.{24798}
Size 5 mg
Shipping dry ice
CAS Number 161804-20-2
Molecular Formula C13H14ClN7O • HCl
SMILES ClC1=C(N)N=C(N)C(C(NC(NCC2=CC=CC=C2)=N)=O)=N1.Cl
Molecular Weight 356,2
Formulation A crystalline solid
Purity ≥98%
Custom Code 2903.99
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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