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Calpain Inhibitor III

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    Calpain Inhibitor III
  • Calpain Inhibitor III
Cat No: 14283
Biochemicals - Small Molecule Inhibitors
Cayman

The calpains are a family of calcium-dependent cysteine proteases that catalyze limited proteolysis of substrates.{13816} Calpain Inhibitor III is a cell permeable, selective inhibitor of μ-calpain (calpain-1) and m-calpain (calpain-2).{22713} Calpain ...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • N-[(1S)-1-[[(1-formyl-2-phenylethyl)amino]carbonyl]-2-methylpropyl]-carbamic acid, phenylmethyl ester
Correlated keywords:
  • 195050-81-8 neurosciences inhibitors inhibits inhibitions cardiology calcium dependent calcium-dependent cysteines proteases catalyzes proteolysis substrates cells permeables selectives µ-calpain micro micro-calpains .micro.-calpains microcalpains µcalpain m-calpain mcalpain m calpain 2 calpain-2 calpain2 blood brains blood-brain barriers neuroprotectives rodents neurotrauma models concussions spines spinal cords injury injuries cortical impacts traumas neonatal hypoxia-ischemia hypoxias ischemias focal cerebral ischemia depression mycocardial contractiles performances reperfusions cadiacs calpain-1 calpain1 1 activity activities protective MDL28170 MDLs MDL-28170 28170 calp III calp-III calpIII 3
Product Overview:
The calpains are a family of calcium-dependent cysteine proteases that catalyze limited proteolysis of substrates.{13816} Calpain Inhibitor III is a cell permeable, selective inhibitor of μ-calpain (calpain-1) and m-calpain (calpain-2).{22713} Calpain Inhibitor III crosses the blood-brain barrier to inhibit brain cysteine protease activity and has been reported to have neuroprotective effects in numerous rodent neurotrauma models, including spinal cord injury, cortical impact trauma, neonatal hypoxia-ischemia, and focal cerebral ischemia.{22714} Additionally, Calpain Inhibitor III has been shown to attenuate depression in myocardial contractile performance that occurs during reperfusion following cardiac ischemia.{22712}
Size 5 mg
Shipping dry ice
CAS Number 88191-84-8
Molecular Formula C22H26N2O4
SMILES O=C(N[C@@H](C(C)C)C(NC(CC1=CC=CC=C1)C([H])=O)=O)OCC2=CC=CC=C2
Molecular Weight 382,5
Formulation A crystalline solid
Purity ≥95%
Custom Code 2922.19
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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