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6-Formylpterin

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    6-<wbr/>Formylpterin
  • 6-<wbr/>Formylpterin
Cat No: 14247
Biochemicals - Small Molecule Inhibitors
Cayman

Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.{15324} 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic a...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 2-amino-3,4-dihydro-4-oxo-6-pteridinecarboxaldehyde
Correlated keywords:
  • 23663-21-0 inhibitors oxidative stress intracellular generators hydrogens peroxides xanthine oxidase XO oxygen species H2O2 formylpterin formyl pterin formul-pterin photolytic folic acids binds binding binder hetero-substrate heterosubstrate hetero substrate inhibits inhibitions 6-carboxylpterin carboxylpterin carboxyl pterin generator cellular
Product Overview:
Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.{15324} 6-Formylpterin is an oxidized pterin produced by photolytic breakdown of folic acid.{24043} It binds to one of two active sites on XO nearly quantitatively and irreversibly and prevents the metabolism of other substrates at the second site, resulting in “hetero-substrate” inhibition at nanomolar concentrations.{24043,24041} However, 6-formylpterin itself is converted by XO to 6-carboxylpterin and H2O2 and the turnover rate of this reaction can actually be accelerated by prior binding of a hetero-substrate to XO.{24041} In this way, 6-formylpterin acts as an intracellular generator of H2O2 in cells expressing XO, altering cellular function.{24042,24039}
Size 500 µg
Shipping dry ice
CAS Number 712-30-1
Molecular Formula C7H5N5O2
SMILES O=C1C2=C(N=CC(C=O)=N2)N=C(N)N1
Molecular Weight 191,1
Formulation A crystalline solid
Purity ≥98%
Custom Code 2922.19
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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