Cycloheximide

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Cycloheximide

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Cat No: 14126

Biochemicals - Natural Products

Cycloheximide is a glutarimide antibiotic produced by S. griseus that inhibits protein synthesis in eukaryotes (IC50 = 5-50 μM) by interfering with translational elongation.{23270} Its effects on protein synthesis can either induce or inhibit apoptosi...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-2,6-piperidinedione

Correlated keywords:

4630-76-6 6399-67-3 17974-04-8 21059-09-6 antibiotics inhibitors inhibits inhibitions proteins synthesis eukaryotes translation elongation apoptosis S. griseus Streptomyces cells types molecular biology biologies ribsome profiling profiles translational half-life half life NSCs 185 NSC185 NSC-185 naramycin-A acti-aid actiaid acti aids acti-dione actidione acti dione BR PM TGF actidion CHX cicloheximide FT 3422-2 FT-3422-2 FT3422-2 34222 3422 2 FT-34222 FT-3422 FT34222 FT3422 LDNs LDN97549 LDN-97549 97549 NM-MCD 80 NMMCD-80 naramycin microcapsule D 80 NM-MCU TZA Us 4527 U-4527 U4527 ferroptosis

Product Overview:
Cycloheximide is a glutarimide antibiotic produced by S. griseus that inhibits protein synthesis in eukaryotes (IC50 = 5-50 μM) by interfering with translational elongation.{23270} Its effects on protein synthesis can either induce or inhibit apoptosis depending on cell type.{23271} Cycloheximide is widely used as a tool in molecular biology research for ribosome profiling and translational profiling as well as to determine the half-life of a protein.{23273,23272}

Size	100 mg
Shipping	dry ice
CAS Number	66-81-9
Molecular Formula	C₁₅H₂₃NO₄
SMILES	O=C1[C@@]([C@H](O)CC2CC(NC(C2)=O)=O)([H])C[C@@H](C)C[C@@H]1C
Molecular Weight	281,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.