OAC1 - C14H11N3O - Bertin Bioreagent

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OAC1

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Cat No: 14102

Biochemicals - Small Molecule Activators

Octamer-binding transcription factor 4 (Oct4) is a transcription factor that, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.{22412,22414} OAC1 is an Oct4-activating compound that activat...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-1H-pyrrolo[2,3-c]pyridin-5-yl-benzamide

Correlated keywords:

genes regulations stems cells research TFs Oct4-activating activating Oct4 Oct-4 OAC-2 OAC2 OAC3 OAC-3 Sox2 Klf4 c-Myc pluripotentcy OAC 2 3 Sox-2 Soxs somatic transcriptions factors promoters enhances iPSCs pluripotent induced embryonic fibroblasts in vitro in vivo activates activations expressions

Product Overview:
Octamer-binding transcription factor 4 (Oct4) is a transcription factor that, with Sox2, Klf4, and c-Myc, is involved in the reprogramming of somatic cells to produce pluripotent stem cells.{22412,22414} OAC1 is an Oct4-activating compound that activates expression through the Oct4 gene promoter.{22003} In cells expressing Oct4 with Sox2, Klf4, and c-Myc, OAC1 (1 μM) enhances reprogramming efficiency by increasing the rate of production of induced pluripotent stem cells (iPSCs) from embryonic fibroblasts.{22003} The iPSCs developed using OAC1 retain the capacity for pluripotent differentiation, whether evaluated in vitro or in vivo.{22003}

Size	5 mg
Shipping	dry ice
CAS Number	300586-90-7
Molecular Formula	C₁₄H₁₁N₃O
SMILES	O=C(NC1=NC=C(NC=C2)C2=C1)C3=CC=CC=C3
Molecular Weight	237,3
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.