?4-Dafachronic Acid

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?⁴-Dafachronic Acid

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Cat No: 14100

Biochemicals - Receptor Pharmacology

During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival.{22033,22027} DAF-12 is an orphan nuclear hormone receptor that regulates dauer la...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-oxo-cholest-4-en-26-oic acid

Correlated keywords:

3-keto-4-cholestenoic acid C. elegan dauer larvae parasites nuclear receptors diapauses reproductive developments metabolism life cycles racemic sterol derived sterol-derived hormones DAF12 DAFs DAF-12 .DELTA.4-dafachronic D4-dafachronic DELTA4-dafachronic lifespans ligands

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During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival.{22033,22027} DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans.{22030,22029,22015} DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. Δ4-Dafachronic acid is a racemic version of a sterol-derived hormone that acts as a ligand of DAF-12.{22030,22032,22014,22028} Δ4-Dafachronic acid binds to and transactivates DAF-12, rescuing hormone deficiency in transgenic dauer larvae and promoting reproductive maturation into adults.{22032,22031,22033} The (25S) diastereomer of Δ4-dafachronic acid is significantly more potent than its (25R) counterpart (EC50s = 23 and 66 nM, respectively).{22014}

Size	1 mg
Shipping	dry ice
CAS Number	23017-97-2
Molecular Formula	C₂₇H₄₂O₃
SMILES	O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4[C@@H](CCCC(C)C(O)=O)C)=C1
Molecular Weight	414,6
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2932.99
UNSPSC code	12352100

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MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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