Timolol (maleate)

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Timolol (maleate)

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Cat No: 13974

Biochemicals - Receptor Pharmacology

Timolol is a non-selective β-adrenergic receptor antagonist with log Kd values of -8.27, -9.86, and -6.8 for binding to human β1-, β2-, and β3-adrenoceptors, respectively.{25151} It has been reported that only the (S) enantiomer contributes to the β-b...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(2S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-2-propanol, 2Z-butenedioate

Correlated keywords:

131628-37-0 194288-09-0 26839-75-8 30166-36-0 116475-10-6 131628-38-1 beta blocker ?-adrenergic b-adrenergic glaucoma ?-1 ?-2 ?-3 b1 b2 b3 b-1 b-2 b-3 intra-ocular apimol aquanil betim betime blocadren blocanol istalol MK950 ocumol ophtamolol optimal proflax rysmon TG temserin tenopt timabak timacar timacor timoftol timohexal timolet timolol LA timomann timoptic timoptol XE timorom WP-934 26839-77-0

Product Overview:
Timolol is a non-selective β-adrenergic receptor antagonist with log Kd values of -8.27, -9.86, and -6.8 for binding to human β1-, β2-, and β3-adrenoceptors, respectively.{25151} It has been reported that only the (S) enantiomer contributes to the β-blocking effects of racemic timolol, but the weakly active (R) isomer maintains a beneficial effect on intraocular pressure without the undesirable side-effect of bronchial constriction caused by non-selective action of (S)-timolol on β1 and β2 receptors.{13497,25396} Timolol has been use alone and in fixed combinations with either prostaglandin analogs or carbonic anhydrase inhibitors to reduce intraocular pressure in research models of ocular hypertension and glaucoma.{23436,16983}

Size	25 mg
Shipping	dry ice
CAS Number	26921-17-5
Molecular Formula	C₁₃H₂₄N₄O₃S • C₄H₄O₄
SMILES	CC(C)(C)NC[C@H](O)COC1=NSN=C1N2CCOCC2.OC(/C=C\C(O)=O)=O
Molecular Weight	432,5
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.