IKK? Monoclonal Antibody (Clone

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IKK? Monoclonal Antibody (Clone 72C627)

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Cat No: 13931

Nuclear Factor-κB (NF-κB) is sequestered in the cytoplasm by the IκB family of inhibitory proteins that mask the nuclear localization signal of NF-κB, thereby preventing translocation of NF-κB to the nucleus.{18540} External stimuli such as tumor necr...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

antibodies I?B? IkBa I?Ba IkB? I?B-? I?B ? antibodies I?B? IkBa I?Ba IkB? I?B-? I?B ? IKK3 IKK-1 IKK-2 IKK-3 1 2 3 IKK1/a IKK1-a IKK1a IKK2/b IKK2-b IKK2b IKK3/g IKK3-g IKK3g IKK IKK1 IKK2 IKK1/? IKK-1/? 1/? IKK2/? IKK-2/? 2/? IKK3/? IKK-3/? 3/? IKK1/.alpha. IKK2/.beta. IKK3/.gamma. IKK1/alpha IKK2/beta IKK3/gamma IKK-1/.alpha. IKK-2/.beta. IKK-3/.gamma. IKK-1/alpha IKK-2/beta IKK-3/gamma 1.alpha. 1alpha 1? 2.beta. 2beta 2? 3.gamma. 3gamma 3? 1-.alpha. 1-alpha 1-? 2-.beta. -2beta 2-? 3-.gamma. 3-gamma 3-? IKKg IKK? IKKgamma IKK.gamma. IKK-g IKK-? IKK-gamma IKK-.gamma. IKK g ? .gamma. gamma cytoplasm inhibitory inhibits inhibitions proteins mask nuclear localization signals translocation nucleus tumors necrosis factors cytokines phosphorylation degradation dimers translocates genes autoregulated auto regulated auto-regulated complex essentials modulators t-cells t cells tcells leukemia virus types 1 one taxes oncoprotein key molecule adapter onco-protein onco oncoprotein signalling signalin western blots WB blotting

Product Overview:
Nuclear Factor-κB (NF-κB) is sequestered in the cytoplasm by the IκB family of inhibitory proteins that mask the nuclear localization signal of NF-κB, thereby preventing translocation of NF-κB to the nucleus.{18540} External stimuli such as tumor necrosis factor or other cytokines result in phosphorylation and degradation of IκB, releasing NF-κB dimers. NF-κB dimers subsequently translocate to the nucleus and activate target genes. Synthesis of IκBα is autoregulated.{18541} IκB proteins are phosphorylated by IκB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and IKK3/γ.{18542,18543,18544,18658,18545} IKKγ preferentially interacts with IKKβ and is required for activation of IKK complex. IKKγ is also known as NF-κB essential modulator (NEMO).{18545} The human T cell leukemia virus type I Tax oncoprotein that activates NF-κB binds neither to IKKα nor IKKβ, but complexes directly with IKKγ.{18659} This suggests that IKKγ may be a key molecule acting as an adapter for oncoprotein specific signaling to IKKα and IKKβ.{18659}

Size	1 ea
Shipping	dry ice
Host	Mouse
Antigen	His-tagged full length human IKK?
Clone	72C627
Isotype	IgG1
Application(s)	WB
Formulation	100 µg of protein G-purified IgG
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.