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DL-AP3

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    DL-<wbr/>AP3
  • DL-<wbr/>AP3
Cat No: 13852
Biochemicals - Receptor Pharmacology
Cayman

Metabotropic glutamate receptors (mGluR1-8) are G protein-coupled receptors that function to modulate brain excitatory signaling via presynaptic, postsynaptic, and glial mechanisms.{21634} DL-AP3 is a competitive mGluR1 antagonist that demonstrates a K...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 3-phosphono-alanine
Correlated keywords:
  • 20263-06-3 2-amino-3-phosphonopropionic acid 3-phosphono-DL-alanine DL-2-amino-2-carboxyethylphosphonic acid DL-2-amino-3-phosphonopropionate phosphonic acid ?-Amino-?-phosphonopropionic NSC30078 NSC-30078 metabotropic glutamate receptors mGluR G protein-coupled receptor excitatory signalings neurosciences LTP antagonists hippocampus glutamate DLAP3 DL AP3 amino acids X syndrome Parkinsons diseases LTP long term potentiation learning memory learn
Product Overview:
Metabotropic glutamate receptors (mGluR1-8) are G protein-coupled receptors that function to modulate brain excitatory signaling via presynaptic, postsynaptic, and glial mechanisms.{21634} DL-AP3 is a competitive mGluR1 antagonist that demonstrates a Ki value of 298 μM and an IC50 value of 1mM for rat mGluR1α when challenged with glutamate.{21635} DL-AP3 can antagonize excitatory amino acid-induced phosphoinositide hydrolysis, induce Ca2+ mobilization in rat hippocampal slices, and inhibit phosphoserine phosphatase in rat brain cortex.{21634,21632} At concentrations from 10-300 μM DL-AP3 has been used to characterize the role of mGluR in long-term potentiation in the hippocampus in a model of learning and memory, the release of glutamate in Parkinson’s disease, and the increased activity of mGluR implicated in fragile X syndrome.{21633,21631,21630}
Size 50 mg
Shipping dry ice
CAS Number 5652-28-8
Molecular Formula C3H8NO5P
SMILES NC(CP(O)(O)=O)C(O)=O
Molecular Weight 169,1
Formulation A crystalline solid
Purity ≥95%
Custom Code 2922.19
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

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