Lansoprazole

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Lansoprazole

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Cat No: 13627

Biochemicals - Small Molecule Inhibitors

Lansoprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase.{43057} It inhibits K+ and H+ accumulation in gastric microsomes in a concentration-dependent manner (IC50s = 6.3 and 7.0 µM, respectively) and inhibits H+/K+-ATPase activity by a...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole

Correlated keywords:

226904-00-3 proton pumps ATPases gastric acids ulcers cytochromes P450 CYP2C19 CYP3A4 Agopton Alter Cinfa Davur Lancid Lanpro Ogastro PP/K-10 154727-72-7 909251-59-8 secretion intra gastric pH increasing Sulfoxides, 2-Methylpyridine 2-Benzimidazole 2-Benzimidazole Sulfoxides, 2-Methylpyridine 2-Methylpyridine 2-Benzimidazole Sulfoxides 2 Methylpyridine 2 Benzimidazole Sulfoxides 2-Pyridinylmethylsulfinyl-2-Benzimidazoles 2 Pyridinylmethylsulfinyl 2 Benzimidazoles Sulfoxides, Benzimidazole Methylpyridine Methylpyridine Sulfoxides, Benzimidazole Benzimidazole Methylpyridine Sulfoxides 2-Pyridinylmethylsulfinylbenzimidazoles 2 Pyridinylmethylsulfinylbenzimidazoles Prevacid

Product Overview:
Lansoprazole is a proton pump inhibitor that inhibits the H+/K+-ATPase.{43057} It inhibits K+ and H+ accumulation in gastric microsomes in a concentration-dependent manner (IC50s = 6.3 and 7.0 µM, respectively) and inhibits H+/K+-ATPase activity by approximately 60% when used at a concentration of 10 µM. Lansoprazole inhibits the H+/K+-ATPase in parietal cells, thus inhibiting gastric acid secretion and increasing intragastric pH.{18250} It is a substituted benzimidazole that binds covalently to proton pumps, providing complete and prolonged inhibition of acid secretion.{18256,18258} Formulations containing lansoprazole have been used as a proton pump inhibitor and in combination with antibiotics in the treatment of H. pylori infections and duodenal ulcer disease.

Size	500 mg
Shipping	dry ice
CAS Number	103577-45-3
Molecular Formula	C₁₆H₁₄F₃N₃O₂S
SMILES	CC1=C(CS(C2=NC(C=CC=C3)=C3N2)=O)N=CC=C1OCC(F)(F)F
Molecular Weight	369,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.29
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.