Halofuginone (hydrochloride)

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Cat No: 13370

Halofuginone is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.{26479} It has antimalarial and anticoccidial actions.{26479} In mammals, halofuginone at 10 ng/ml down-regulat...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

7-bromo-6-chloro-3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone, monohydrochloride

Correlated keywords:

55837-20-2 inhibitors inhibitions inhibits cancers genes regulations autoimmunity infectious diseases immunology HCl TGF-? TGF-.beta. TGF-beta TGF-b TGF ? .beta. beta b signals signaling TH17 differentiation derivatives febrifugine D. D febrifuga antimalarial anti-malarial anti malarial malaria anticoccidial anti-coccidial coccidial Smad3 fibroblasts myofibroblasts epithelial cells mesenchymal fibrosis tumors competitive competitively prolyl-tRNA prolyl tRNA synthetase monohydrochloride autoimmune diseases

Product Overview:
Halofuginone is a halogenated derivative of febrifugine, a natural quinazolinone-containing compound found in the Chinese herb D. febrifuga.{26479} It has antimalarial and anticoccidial actions.{26479} In mammals, halofuginone at 10 ng/ml down-regulates Smad3, blocking TGF-β signaling and preventing both the differentiation of fibroblasts to myofibroblasts and the transitioning of epithelial cells to mesenchymal cells.{26479,26481} Through this action, halofuginone blocks fibrosis and tumor progression in a variety of different models.{26479,26482} This compound also competitively inhibits prolyl-tRNA synthetase (Ki = 18.3 nM), activating the amino acid starvation response.{26480,17217} This prevents the differentiation of TH17 cells, blunting an autoimmune response.{17217}

Size	500 µg
Shipping	dry ice
CAS Number	1217623-74-9
Molecular Formula	C₁₆H₁₇BrClN₃O₃ • HCl
SMILES	BrC1=C(Cl)C=C2C(N=CN(CC(C[C@H]3NCCC[C@@H]3O)=O)C2=O)=C1.Cl
Molecular Weight	451,1
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.