MF63 - C23H11ClN4 - Bertin Bioreagent

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MF63

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Cat No: 13217

Biochemicals - Small Molecule Inhibitors

Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the terminal enzyme in the biosynthesis of PGE2.{19887,16438,18830} MF63 is a potent, selective, and orally active inhibitor of human mPGES-1 (IC50 = 1.3 nM).{27593,27594} It displays greater than 1,0...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile

Correlated keywords:

biochemical inhibitor prostaglandin inflammation cancer pain arthritis inhibit PGs selective orally microsomal E2 synthase-1 one mPGES-1 mPGES1 enzyme PGE2 human guinea pig mice mouse lipopolysaccharide-induced LPS-induced pyresis hyperalgesia iodoacetate-induced osteoarthritic osteoarthritis suppress synthesis stomach MF 63

Product Overview:
Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the terminal enzyme in the biosynthesis of PGE2.{19887,16438,18830} MF63 is a potent, selective, and orally active inhibitor of human mPGES-1 (IC50 = 1.3 nM).{27593,27594} It displays greater than 1,000-fold selectivity over other prostanoid synthases.{27594} MF63 also potently inhibits guinea pig mPGES-1 (IC50 = 0.9 nM) but not mouse or rat mPGES-1.{27594} In guinea pigs or in mice expressing human mPGES-1, MF63 prevents LPS-induced pyresis, hyperalgesia, and iodoacetate-induced osteoarthritic pain.{27594} It does not produce the gastrointestinal toxicity that is caused by non-selective COX inhibitors, although it markedly suppresses PGE2 synthesis in the stomach.{27594}

Size	1 mg
Shipping	room temp.
CAS Number	892549-43-8
Molecular Formula	C₂₃H₁₁ClN₄
SMILES	ClC1=CC2=C(C=CC=C3)C3=C(NC(C4=C(C#N)C=CC=C4C#N)=N5)C5=C2C=C1
Molecular Weight	378,8
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.