trans-Resveratrol-d4

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trans-Resveratrol-d₄

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Cat No: 13130

Biochemicals - Isotopically Labeled Standards

trans-Resveratrol-d4 is intended for use as an internal standard for the quantification of trans-resveratrol (Item No. 70675) by GC- or LC-MS. trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has ant...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-[(1E)-2-(4-hydroxyphenyl)ethenyl]-1,3-benzenediol-2,3,5,6-d4

Correlated keywords:

selective cyclooxygenases inhibitors COX1 PGHS-1 COX1 PGHS1 prostaglandins H synthases 1 anti-oxidants antiinflammatory cancer oxidative injury stress atherosclerosis deuterated LC/MS GCMS LCMS mass spectrometry deuterium sirtuins AHR antagonists aryl hydrocarbon receptors Caenorhabditis Drosophila JNK-1 ERK-1 deuterated deuterium

Product Overview:
trans-Resveratrol-d4 is intended for use as an internal standard for the quantification of trans-resveratrol (Item No. 70675) by GC- or LC-MS. trans-Resveratrol is a polyphenolic phytoalexin found in a variety of plants, including grapes, that has anti-inflammatory, antioxidant, and anticancer activities.{3491,43362} It inhibits the cyclooxygenase and hydroperoxidase activities of COX-1 (EC50s = 15 and 3.7 μM, respectively), but not COX-2 (EC50s = >100 μM and 85 μM, respectively).{3491} trans-Resveratrol (3 and 8 mg/kg) inhibits carrageenan-induced paw edema in mice. It inhibits free radical formation in HL-60 human promyelocytic leukemia cells induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014; EC50 = 27 μM). trans-Resveratrol (1-25 μmol) reduces both the incidence and number of tumors in a two-stage mouse model of skin cancer induced by TPA and 7,12-dimethyl-benz[a]anthracene (DMBA). trans-Resveratrol (200 μM) also activates sirtuin 1 (SIRT1) by 8-fold in vitro and inhibits a variety of targets including ERK1, JNK1, Src, PKCα, aromatase/CYP19, and DNA polymerases α and δ (IC50s = 37, 50, 20, in vitro and/or ex vivo.{13296,43362} It prolongs lifespan in model organisms including C. elegans, D. melanogaster, and mice.{43362}

Size	100 µg
Shipping	dry ice
CAS Number	1089051-56-8
Molecular Formula	C₁₄H₈D₄O₃
SMILES	Oc1ccc(cc1)\C=C/c1cc(O)cc(O)c1
Molecular Weight	232,3
Formulation	A solution in ethanol
Purity	≥99% deuterated forms (d1-d4)
Custom Code	3822.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

trans-Resveratrol-d₄

trans-Resveratrol-d₄