Emodin

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Emodin

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Cat No: 13109

Biochemicals - Kinase Inhibitors

Emodin is a naturally-occurring anthraquinone found in a variety of plants used in traditional Chinese medicine. Purified emodin has diverse effects, including the suppression of inflammation, dyslipidemia, and cancer.{21482,21479,21480} At a molecula...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1,3,8-trihydroxy-6-methyl-9,10-anthracenedione

Correlated keywords:

emodol frangula rheum NSC408120 NSC-408120 NSC622947 NSC-622947 natural products cancers inflammation estrogen receptors apoptosis dyslipidemia receptors agonists CSN ER anthraquinone plants suppression inhibits inhibition inhibitors casein kinases II tumors suppressors p53 phytoestrogen CK II

Product Overview:
Emodin is a naturally-occurring anthraquinone found in a variety of plants used in traditional Chinese medicine. Purified emodin has diverse effects, including the suppression of inflammation, dyslipidemia, and cancer.{21482,21479,21480} At a molecular level, emodin directly and selectively inhibits casein kinase II (IC50 = 0.89 μM).{21491,21488} Through this action, it inhibits the COP9 signalosome, causing the stabilization of the tumor suppressor p53.{21488} Moreover, emodin acts as a phytoestrogen, binding human estrogen receptors and blocking 17β-estradiol binding with Ki values of 0.77 and 1.5 μM for ERα and ERβ, respectively.{21490}

Size	25 mg
Shipping	dry ice
CAS Number	518-82-1
Molecular Formula	C₁₅H₁₀O₅
SMILES	OC1=CC(C)=CC2=C1C(C3=C(O)C=C(O)C=C3C2=O)=O
Molecular Weight	270,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2907.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.