1a,1b-dihomo Prostaglandin E₁

Biochemicals - Lipids

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Cat No: 13050

Biochemicals - Lipids

Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology.{22,3803} COX metabolism of ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

[1R-[1?,2?(1E,3S*),3?]]-3-hydroxy-2-(3-hydroxy-1-octenyl)-5-oxo-cyclopentanenonanoic acid

Correlated keywords:

23453-25-0 1a,1b-dihomo-PGE1 prostaglandins

Product Overview:
Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology.{22,3803} COX metabolism of the unusual fatty acid 10,13,16-docosatrienoic acid yields 1a,1b-dihomo PGE1. This rare metabolite has been recovered from incubations of whole sheep seminal vesicles, but has not been reported in humans.{11211} In ex vivo preparations of rat aorta and rat PRP, 1a,1b-dihomo PGE1 was found to be much less active than PGE1 itself.{11212}

Size	1 mg
Shipping	dry ice
CAS Number	23452-98-4
Molecular Formula	C₂₂H₃₈O₅
SMILES	O[C@H]1[C@H](/C=C/[C@@H](O)CCCCC)[C@@H](CCCCCCCCC(O)=O)C(C1)=O
Molecular Weight	382,5
Formulation	A solution in methyl acetate
Purity	≥98%
Custom Code	2937.50
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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