11-deoxy-11-methylene Prostaglan

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11-deoxy-11-methylene Prostaglandin D₂

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Cat No: 12410

Biochemicals - Lipids

Prostaglandin D2 (PGD2; Item No. 12010) is one of the five primary enzymatic prostaglandins derived directly from PGH2 (Item No. 17020). PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells in...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

9?,15S-dihydroxy-11-methylene-prosta-5Z,13E-dien-1-oic acid

Correlated keywords:

11-deoxy-11-methylene-PGD2 vasodilation prostaglandins analogs

Product Overview:
Prostaglandin D2 (PGD2; Item No. 12010) is one of the five primary enzymatic prostaglandins derived directly from PGH2 (Item No. 17020). PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, leukocyte-type PGD synthase.{9588} PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. 11-deoxy-11-methylene PGD2 is a novel, chemically stable, isosteric analog of PGD2 wherein the 11-keto group is replaced by an exocyclic methylene. In the PGE series, the analogous modification leads to a stable, somewhat less potent agonist which embodies the same uterine stimulant and cervical ripening activities as the parent prostaglandin.{7894} However, 11-deoxy-11-methylene PGD2 has been reported by one group to be essentially without agonist activity on human platelets, a DP1 receptor assay.{11175} The CRTH2-receptor actions of 11-deoxy-11-methylene PGD2 are not yet reported.

Size	1 mg
Shipping	dry ice
CAS Number	100648-29-1
Molecular Formula	C₂₁H₃₄O₄
SMILES	O[C@@H](C1)[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)C1=C
Molecular Weight	350,5
Formulation	A solution in methyl acetate
Purity	≥98%
Custom Code	2937.50
UNSPSC code	12352100

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11-deoxy-11-methylene Prostaglandin D2