Tandutinib

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Tandutinib

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Cat No: 12098

Biochemicals - Kinase Inhibitors

Tandutinib is a potent antagonist of platelet-derived growth factor receptor β (PDGFRβ), FLT3, and c-Kit (IC50 = 200, 220, and 170 nM, respectively).{24623} It less potently inhibits macrophage colony-stimulating factor 1 receptor (IC50 = 3.4 µM) and ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide

Correlated keywords:

CSF-1R CSF1R CSFs 1R colony stimulating factors 1 receptors colony-stimulating PDGFR PDGFR? ?PDGFR inhibitors inhibits inhibitions antagonists kinases signals transduction cancers FLT3-ITD FLT2ITD FLT3 IDT MLNs MLN518 MLN-518 518 CTs 53518 CT53518 CT-53518 Flt-3 flts 3 three c-Kit c Kit cKit

Product Overview:
Tandutinib is a potent antagonist of platelet-derived growth factor receptor β (PDGFRβ), FLT3, and c-Kit (IC50 = 200, 220, and 170 nM, respectively).{24623} It less potently inhibits macrophage colony-stimulating factor 1 receptor (IC50 = 3.4 µM) and does not significantly inhibit other tyrosine or serine/threonine kinases.{24623,24622} Tandutinib blocks the growth of cells expressing an internal tandem duplication within the juxtamembrane domain of the FLT3 receptor, found in some acute myelogenous leukemia cells.{24623,24624} It also impairs the growth of colon cancer cells through its actions on the c-Kit receptor.{24621} Tandutinib reverses multidrug resistance in vitro by impairing the efflux activity of the multidrug resistance protein 7.{24625}

Size	25 mg
Shipping	dry ice
CAS Number	387867-13-2
Molecular Formula	C₃₁H₄₂N₆O₄
SMILES	O=C(NC1=CC=C(OC(C)C)C=C1)N(CC2)CCN2C3=NC=NC4=C3C=C(OC)C(OCCCN5CCCCC5)=C4
Molecular Weight	562,7
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.59
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.