Epirubicin (hydrochloride)

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Cat No: 12091

Epirubicin is a stereoisomer of the antitumor anthracycline doxorubicin (Item No. 15007) that undergoes β-glucuronidation, which partially detoxifies the dose-limiting side effects that are present with doxorubicin.{22870} Compared to doxorubicin, epi...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(8S,10S)-10-[(3-amino-2,3,6-trideoxy-?-L-arabino-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione, monohydrochloride

Correlated keywords:

56420-45-2 4-epidoxorubicin antitumors anti-tumors tumors anti anthracycline doxorubicin ?-glucuronidation cytotoxic .beta.-glucuronidation beta-glucuronidation b-glucuronidation glucuronidation b beta .beta. ??cytotoxic HeLa cells therapies remissions cancers ovary ovarian lymphomas breasts pancreas gastric hepatocellular carcinomas heads necks colorectal epidoxorubicin 4s fours HCls Ellence farmorubicin pharmorubicin antibiotics inhibitors inhibits inhibitions epirubicin stereoisomers detoxifies dose-limiting doses limiting sides effects

Product Overview:
Epirubicin is a stereoisomer of the antitumor anthracycline doxorubicin (Item No. 15007) that undergoes β-glucuronidation, which partially detoxifies the dose-limiting side effects that are present with doxorubicin.{22870} Compared to doxorubicin, epirubicin is equally cytotoxic to HeLa cells (ID50s = 9 μM).{22870} When used either alone or in combination therapies, epirubicin has been shown to demonstrate high rates of complete or partial remission in various cancers including advanced ovary, lymphomas, breast, pancreas, gastric, hepatocellular carcinoma, head and neck tumors, and colorectal.{22870,20978}

Size	5 mg
Shipping	dry ice
CAS Number	56390-09-1
Molecular Formula	C₂₇H₂₉NO₁₁ • HCl
SMILES	O=C1C2=C(C(O)=C(C[C@](C(CO)=O)(O)C[C@@H]3O[C@@]4([H])C[C@H](N)[C@@H](O)[C@H](C)O4)C3=C2O)C(C5=CC=CC(OC)=C51)=O.Cl
Molecular Weight	580
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.