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Abnormal Cannabidiol

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    Abnormal Cannabidiol
  • Abnormal Cannabidiol
Cat No: 10004259
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A GPR55 agonist (EC50s = 2.5, >30, and >30 µM, for GRP55, CB1, and CB2 receptors, respectively); a full agonist at GPR18 (EC50 = 0.835 µM); regulates migratory activity of murine BV-2 microglial cells (EC50 = 0.6 µM); has various vasodilatory effects, ...


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Territorial Availability: Available through Bertin Technologies only in Europe
  • 4-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol
  • Abn-CBD
Correlated keywords:
  • endocannabinoids
  • cannabidiols
  • abnormal
  • non-CB1
  • non-CB2
  • receptors
  • agonists
  • BV-2
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Product Overview:
A GPR55 agonist (EC50s = 2.5, >30, and >30 µM, for GRP55, CB1, and CB2 receptors, respectively); a full agonist at GPR18 (EC50 = 0.835 µM); regulates migratory activity of murine BV-2 microglial cells (EC50 = 0.6 µM); has various vasodilatory effects, decreasing blood pressure when administered at a dose of 20 µg/g in rats
Abnormal cannabidiol is a synthetic cannabidiol that acts as an agonist at the GPR55 cannabinoid (CB) receptor and is highly selective for GPR55 over CB1 and CB2 receptors (EC50s = 2.5, >30, and >30 µM, respectively). It is also a full agonist at GPR18, with an EC50 value of 0.835 µM for inducing p44/42 MAPK phosphorylation in HEK293 cells stably transfected with GPR18. Abnormal cannabidiol regulates the migratory activity of murine BV-2 microglial cells, with an EC50 value of 0.6 µM. It induces endothelium-dependent vasodilation via a CB1/CB2/NO-independent mechanism and inhibits vasoconstriction induced by endothelin 1 (ET-1) in retinal arterioles, an effect that can be blocked by apamin (Item No. 17082), a calcium-sensitive potassium channel blocker. It also decreases blood pressure in anesthetized rats when administered intravenously at a dose of 20 µg/g or when administered directly into the rostral ventrolateral medulla.
Size 1 mg
Shipping wet ice
Stability Store at -20 degrees; shelf life 730 days maximum after production
CAS Number 22972-55-0
Molecular Formula C21H30O2
Molecular Weight 314.5
Formulation A solution in methyl acetate
Purity ≥98%
Custom Code 2932996560
UNSPSC code 12352100
UN Number UN1231

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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