CID-2745687

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CID-2745687

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Cat No: 12046

Biochemicals - Receptor Pharmacology

GPR35 is a G protein-coupled receptor that is activated by kynurenic acid and 2-acyl lysophosphatidic acids (e.g., 2-oleoyl lysophosphatidic acid).{24499,14771,24500} It is expressed predominantly on immune cells, the brain, and in the gastrointestinal...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-(2,4-difluorophenyl)-5-[[2-[[(1,1-dimethylethyl)amino]thioxomethyl]hydrazinylidene]methyl]-1H-pyrazole-4-carboxylic acid, methyl ester

Correlated keywords:

receptors antagonists neurosciences cancers immunology CID9581011 CIDs 2745687 CID2745687 9581011 CID-9581011 MLs 194 ML-194 ML194 GPRs 35 GPR35 GPR-35 G proteins coupled kynurenic acids pamoic zaprinast protein-coupled activated activates 2-acyl 2 acyl lysophosphatidic 2-oleoyl oleoyl immune cells brains gastrointestinal tracts GI gastric CID-2745687 CID9581011 reversible competitive blocking blocks synthetic agonists activations 10010421 selectivity GPR55 GPR-55 55

Product Overview:
GPR35 is a G protein-coupled receptor that is activated by kynurenic acid and 2-acyl lysophosphatidic acids (e.g., 2-oleoyl lysophosphatidic acid).{24499,14771,24500} It is expressed predominantly on immune cells, the brain, and in the gastrointestinal tract.{14857,14771} GPR35 is overexpressed in gastric cancer cells.{13309} CID-2745687 is a reversible, competitive antagonist of GPR35, blocking activation by the synthetic agonist pamoic acid with a Ki value of 12.8 nM.{24501} It less potently blocks activation of GPR35 by zaprinast (Item No. 10010421) (IC50 = 160 nM).{24498} It shows ~57-fold selectivity for GPR35 over the related receptor GPR55 (IC50 = 9.08 µM).{24498}

Size	5 mg
Shipping	dry ice
CAS Number	264233-05-8
Molecular Formula	C₁₇H₁₉F₂N₅O₂S
SMILES	O=C(OC)C1=C(/C=N/NC(NC(C)(C)C)=S)N(C2=CC=C(F)C=C2F)N=C1
Molecular Weight	395,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2903.99
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.