Ro 67-4853

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Ro 67-4853

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Cat No: 11992

Biochemicals - Receptor Pharmacology

Ro 67-4853 is a positive allosteric modulator of metabotropic glutamate 1 receptors (mGluR1), enhancing glutamate-induced calcium signaling through both the human and mouse mGlu1a receptors (pEC50 = 7.16).{22051,22050} While only mildly potentiating m...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-(9H-xanthen-9-ylcarbonyl)-carbamic acid, butyl ester

Correlated keywords:

glutamate neuroscience receptors allosteric modulators calcium metabotropic glutamate Ro67-4853 Ro674853 Ro67,4853 Ro67 4853 67-4853 674853 67,4853 Ros Ro-67-4853 Ro-674853 Ro-67,4853 mGluRs mGlus mGlu1a mGluR5 activate kidney cells phosphorylation ERK1/2 adenylate cyclase DHPG in vivo in vitro

Product Overview:
Ro 67-4853 is a positive allosteric modulator of metabotropic glutamate 1 receptors (mGluR1), enhancing glutamate-induced calcium signaling through both the human and mouse mGlu1a receptors (pEC50 = 7.16).{22051,22050} While only mildly potentiating mGluR5 signaling, this compound is without effect at mGluR2, mGluR4, or mGluR8, as well as at several other neural receptors.{22051} Ro 67-4853 can also directly activate mGluR1 signaling in baby hamster kidney cells, leading to phosphorylation of ERK1/2 (EC50 = 6.2 nM) and activation of adenylate cyclase (EC50 = 11.7 μM).{22053} Ro 67-4853 can also be used to enhance neuronal stimulation in response to the mGluR1/mGluR5 agonist DHPG, both in vivo and in vitro (EC50 = 95 nM).{22051,22052}

Size	1 mg
Shipping	room temp.
CAS Number	302841-89-0
Molecular Formula	C₁₉H₁₉NO₄
SMILES	O=C(NC(OCCCC)=O)C1C2=CC=CC=C2OC3=C1C=CC=C3
Molecular Weight	325,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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