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Ro 01-6128

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    Ro 01-<wbr/>6128
  • Ro 01-<wbr/>6128
Cat No: 11991
Biochemicals - Receptor Pharmacology
Cayman

Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites on certain mGluR subtypes are being developed to p...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • N-(2,2-diphenylacetyl)-carbamic acid, ethyl ester
Correlated keywords:
  • glutamates metabotropic receptors mGluR1 positive allosteric modulators Ro-01-6128 Ro-016128 Ro-01,6128 Ro01-6128 Ro016128 Ro01,6128 Ro 016128 Ro 01,6128 mGluRs mGluR1a ERK1/2 cAMP
Product Overview:
Glutamate, the major excitatory neurotransmitter in the CNS, activates eight known subtypes of metabotropic glutamate receptors (mGluRs). Highly selective modulators designed to act at allosteric sites on certain mGluR subtypes are being developed to preferentially regulate subtype-specific, glutamate-induced receptor activation.{22053} Ro 01-6128 is a positive allosteric modulator of mGluR1 that can potentiate glutamate-induced calcium release at rat mGluR1a with an EC50 value of 104 nM.{22051,22050} Ro 01-6128 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate with an EC50 value of 248 nM and potentiates glutamate-induced cAMP production with an EC50 value of 21.5 μM.{22053}
Size 1 mg
Shipping dry ice
CAS Number 302841-86-7
Molecular Formula C17H17NO3
SMILES O=C(NC(OCC)=O)C(C1=CC=CC=C1)C2=CC=CC=C2
Molecular Weight 283,3
Formulation A crystalline solid
Purity ≥98%
Custom Code 2922.19
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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