Pyripyropene A

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Pyripyropene A

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Cat No: 11896

Biochemicals - Natural Products

Acyl-CoA: cholesterol acyltransferase (ACAT) is a key enzyme for cholesteryl ester accumulation in atherogenesis, lipoprotein formation in liver, and cholesterol absorption from intestines, all of which are events that contribute to the atherosclerotic...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3,6-bis(acetyloxy)-4-[(acetyloxy)methyl]-1,3S,4R,4aR,5,6S,6aS,12R,12aS,12bS-decahydro-12-hydroxy-4,6a,12b-trimethyl-9-(3-pyridinyl)-2H,11H-naphtho[2,1-b]pyrano[3,4-e]pyran-11-one

Correlated keywords:

167897-54-3 FO1289A FO-1289A cardiovascular diseases ACAT Acyl-CoA: cholesterol acyltransferase atherosclerosis inhibitors ACT1 ACAT2 cholesterol absorption inhibits inhibitions Aspergillus fumigates A. fumigates in vitro VLDL LDL lowe density lipoprotein

Product Overview:
Acyl-CoA: cholesterol acyltransferase (ACAT) is a key enzyme for cholesteryl ester accumulation in atherogenesis, lipoprotein formation in liver, and cholesterol absorption from intestines, all of which are events that contribute to the atherosclerotic process.{13122,14056} Two ACAT isozymes have been identified and are expressed in distinct tissues. ACAT1 is ubiquitously expressed at a high level in sebaceous glands, steroidogenic tissues, and macrophages, whereas ACAT2 is expressed predominantly in the liver and intestine.{11763} Pyripyropene A, naturally produced by A. fumigates, is a potent inhibitor of ACAT2 with an IC50 value of 70 nM in an in vitro activity assay.{21763,21761,21762} It demonstrates high selectivity for the ACAT2 isozyme, inhibiting ACAT1 in a similar assay with an IC50 value of > 80 μM.{21762} A dose of 10 to 100 mg/kg PPPA inhibits cholesterol absorption in mouse intestine by 30.5-55%.{21762} Oral administration to apolipoprotein E-knockout mice at 10-50 mg/kg per day for 12 weeks can lower the levels of plasma cholesterol and hepatic cholesterol, very-low-density lipoprotein, and LDL content, resulting in protection from atherosclerosis development.{21762}

Size	250 µg
Shipping	dry ice
CAS Number	147444-03-9
Molecular Formula	C₃₁H₃₇NO₁₀
SMILES	O=C1OC(C2=CN=CC=C2)=CC3=C1[C@H](O)[C@@]4([H])[C@@](O3)(C)[C@@H](OC(C)=O)C[C@@]5([H])[C@@](COC(C)=O)(C)[C@@H](OC(C)=O)CC[C@@]54C
Molecular Weight	583,6
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.39
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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