Veratramine

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Veratramine

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Cat No: 11724

Biochemicals - Natural Products

The hedgehog (Hh) signaling pathway, which is blocked by cyclopamine (Item No. 11321), plays a key role in morphogenesis and has potential applications in the treatment of cancer.{20489,20491,18038} Veratramine, a teratogenic steroidal alkaloid isolate...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5S-methyl-2S-[1S-[2,3S,4,6,6aR,11,11aS,11bR-octahydro-3R-hydroxy-10,11b-dimethyl-1H-benzo[a]fluoren-9-yl]ethyl]-3-piperidinol

Correlated keywords:

10159-78-1 NSC17821 NSC-17821 NSC23880 NSC-23880 hedgehogs cyclopamine morphogenesis cancers tumors thrombosis platelet aggregation serotonins Hh tetratogenic steroidal alkaloid corn lily veratrum sp. analogs inhibits inhibitors inhibitions re-uptake reuptake uptake CNS signaling

Product Overview:
The hedgehog (Hh) signaling pathway, which is blocked by cyclopamine (Item No. 11321), plays a key role in morphogenesis and has potential applications in the treatment of cancer.{20489,20491,18038} Veratramine, a teratogenic steroidal alkaloid isolated from the corn lily (Veratrum sp.), is an analog of cyclopamine that can inhibit the Hh signaling-dependent proliferation of NIH/3T3 cells at 8 μM.{21777} Additionally, veratramine has anti-thrombotic activity as it dose dependently inhibits platelet aggregation in rabbits ex vivo. While it may be most useful as a signal transduction inhibitor for treating tumors, veratramine also induces serotonin release and inhibits its re-uptake in the CNS.{21779,21778}

Size	5 mg
Shipping	dry ice
CAS Number	60-70-8
Molecular Formula	C₂₇H₃₉NO₂
SMILES	C[C@H]1C[C@@H](O)[C@@]([C@@H](C)C2=C(C)C(C[C@@]3([H])[C@@]4([H])CC=C5[C@]3(C)CC[C@H](O)C5)=C4C=C2)([H])NC1
Molecular Weight	409,6
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.39
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.