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Biochanin A

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    Biochanin A
  • Biochanin A
Cat No: 16476
Cayman
€33.00
Price is excluding VAT and does not include packaging neither shipping

A phytoestrogen that can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity; activates PPARγ (IC50 = 19 µM) and increases the expression of PGC-1α; also inhibits FAAH (IC50 = 2...

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one
  • 4’-methyl Genistein
  • 5,7-dihydroxy-4'-Methoxyisoflavone
  • NSC 123538
Correlated keywords:
  • natural
  • product
  • inhibit
  • receptor
  • agonist
  • flavonoid
  • endocrinology
  • intracellular
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Product Overview:
A phytoestrogen that can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity; activates PPARγ (IC50 = 19 µM) and increases the expression of PGC-1α; also inhibits FAAH (IC50 = 2.4 µM) and agonizes AhR (EC50 = 0.25 µM)
Biochanin A is a natural isoflavone with diverse biological actions, most notably as a phytoestrogen. It can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity. Also known as 4’-methyl genistein, biochanin A can be metabolized in vivo to genistein (Item No. 10005167), another phytoestrogen with diverse effects. Biochanin A also intersects with signaling through peroxisome proliferator-activated receptors (PPARs), as it activates PPARγ (IC50 = 19 µM) and has also been shown to activate a PPARα promoter. Moreover, it increases the expression of the PPARγ coactivator PGC-1α, promoting mitochondrial biogenesis. Biochanin A also inhibits fatty acid amide hydrolase (IC50 = 2.4 µM) and acts as an agonist of the aryl hydrocarbon receptor (EC50 = 0.25 µM).
Size 100 mg
Shipping wet ice
Stability Store at -20 degrees; shelf life 730 days maximum after production
CAS Number 491-80-5
Molecular Formula C16H12O5
SMILES O=C1C2=C(O)C=C(O)C=C2OC=C1C3=CC=C(OC)C=C3
Molecular Weight 284.3
Formulation A crystalline solid
Purity ≥98%
Custom Code 2932996560
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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