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Actinomycin D

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    Actinomycin D
  • Actinomycin D
Cat No: 11421
Biochemicals - More Biochemicals
Cayman
€69.00
Price is excluding VAT and does not include packaging neither shipping

Actinomycin D is a cyclic polypeptide-containing antibiotic that binds to DNA and blocks transcription. It binds to pre-melted double-stranded DNA in transcription bubbles and once bound is slow to dissociate.{21521,21519} DNA in transcriptionally hype...

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Territorial Availability: Available through Bertin Pharma only in Europe
Synonyms:
  • 2-amino-N,N'-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide
Correlated keywords:
  • 1402-51-3 1402-58-0 C1 AIV I1 IV X1 A IV 7 AD actinomycindioic D acid dilactone chounghwamycin B dactinomycin D lyovac NCIC04682 NCI-C04682 NSC3053 NSC-3053 antibiotics DNAs transcriptions RNAs synthesis anticancers cells deaths antitumors anti-cancers anti cancers anti-tumors anti tumors agents fluorescent derivative 7-aminoactinomycin 7-AAD AAD 7AAD markers actinomycin-d
Product Overview:
Actinomycin D is a cyclic polypeptide-containing antibiotic that binds to DNA and blocks transcription. It binds to pre-melted double-stranded DNA in transcription bubbles and once bound is slow to dissociate.{21521,21519} DNA in transcriptionally hyperactive cancer cells efficiently and rapidly bind actinomycin D at low concentrations (~10 nM), which interferes with RNA synthesis and ultimately leads to cell death.{21521,21520} Actinomycin D is widely used as an anticancer agent for treating a variety of tumors and along with its fluorescent derivative, 7-aminoactinomycin D (Item No. 11397) has become a useful tool in biochemistry and molecular biology research as a marker for DNA.
Size 5 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 50-76-0
Molecular Formula C62H86N12O16
SMILES CC1=C2C(C(C(N[C@H](C(N[C@@H](C(C)C)C(N3[C@@](C(N(C)CC4=O)=O)([H])CCC3)=O)=O)[C@@H](C)OC([C@H](C(C)C)N4C)=O)=O)=C(N)C1=O)=NC5=C(C(N[C@@H]([C@@H](C)OC([C@H](C(C)C)N(C)C(CN(C([C@]6([H])CCCN6C([C@H](C(C)C)N7)=O)=O)C)=O)=O)C7=O)=O)C=CC(C)=C5O2
Molecular Weight 1255,5
Formulation A crystalline solid
Purity ≥95%
Custom Code 2922.19
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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