b-AP15

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b-AP15

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Cat No: 11324

Biochemicals - Small Molecule Inhibitors

Proteasome-associated deubiquitinases (DUBs) release ubiquitin from proteasome-targeted ubiquitinated proteins, regenerating free ubiquitin.{25593} b-AP15 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-termi...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3E,5E-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-4-piperidinone

Correlated keywords:

330450-45-8 inhibitors cancers ubiquitin proteasomes deubiquitinases USPs UCHLs USP-14 USP14 14 UCHL-5 UCHL5 proteasome-associated DUBs b AP15 bAP15 ubiquitin-specific-processing protease 14 specific processing process carboxyl-terminal hydrolase isozyme L5 carboxyl terminal in vivo tumor cells T cells apoptosis TNF IV

Product Overview:
Proteasome-associated deubiquitinases (DUBs) release ubiquitin from proteasome-targeted ubiquitinated proteins, regenerating free ubiquitin.{25593} b-AP15 is an inhibitor of ubiquitin-specific-processing protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5), two proteasome-associated DUBs.{20322} It inhibits DUB activity in purified 19S proteasomes with an IC50 value of 2.1 µM.{20322} It exhibits little or no activity against several other DUBs.{20322} Through its effects on USP14 and UCHL5, b-AP15 blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia.{20322,25591} b-AP15 also renders tumor cells sensitive to TNF-mediated apoptosis by natural killer and T cells.{25592}

Size	1 mg
Shipping	dry ice
CAS Number	1009817-63-3
Molecular Formula	C₂₂H₁₇N₃O₆
SMILES	O=C(C=C)N(C/C(C/1=O)=C\C2=CC=C([N+]([O-])=O)C=C2)CC1=C/C3=CC=C([N+]([O-])=O)C=C3
Molecular Weight	419,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.39
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.