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Sodium 4-Phenylbutyrate

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    Sodium 4-<wbr/>Phenylbutyrate
  • Sodium 4-<wbr/>Phenylbutyrate
Cat No: 11323
Biochemicals - Small Molecule Inhibitors
Cayman

Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.{23406,23405} It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, ...

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This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • benzenebutanoic acid, monosodium salt
Correlated keywords:
  • sodium 4-phenylbutyrate 4-PBA 4-phenyl-butyric acid 4-PB chaperones proteins misfolding inhibitors histones deacetylases HDAC cells cycles arrests differentiations apoptosis cancers gliomas myelodysplastic syndromes urea disorders sodiums phenylbutyrate NSCs 657802 NSC657802 NSC-657802 myelodysplastic inhibits inhibitions rescues trafficking misfolded blocks activity tumors 4 clinical trials treatments recurrent malignant treating benzenebutanoic acids Na+
Product Overview:
Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.{23406,23405} It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors.{17643,23404} Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.{23403}
Size 1 g
Shipping dry ice
CAS Number 1716-12-7
Molecular Formula C10H11O2 • Na
SMILES O=C(CCCC1=CC=CC=C1)[O-].[Na+]
Molecular Weight 186,2
Formulation A crystalline solid
Purity ≥98%
Custom Code 2915.60
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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