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Resolvin D2-d5

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    Resolvin D2-<wbr/>d<sub>5</sub>
  • Resolvin D2-<wbr/>d<sub>5</sub>
Cat No: 11184
Biochemicals - Isotopically Labeled Standards

Resolvin D2-d5 (RvD2-d5) is intended for use as an internal standard for the quantification of resolvin D2 (Item No. 10007279) by GC- or LC-MS. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahe...


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Territorial Availability: Available through Bertin Technologies only in France
  • 7S,16R,17S-trihydroxy-4Z,8E,10Z,12E,14E,19Z-21,21’,22,22,22-d5 docosahexaenoic acid
Correlated keywords:
  • LC-MS LC/MS GC-MS GC/MS mass spectrometry MS deuterateds deuteriums EPA DHA inflammation anti-inflammatory antiinflammatory immune responses sepsis Docosahexaenoic Acid 4,7,10,13,16,19-(Z,Z,Z,Z,Z,E-Isomer) Docosahexaenoic Acid 4,7,10,13,16,19-(All-Z-Isomer) Docosahexaenoic Acid 4,7,10,13,16,19-Isomer Docosahexaenoic Acid 3,6,9,12,15,18-Isomer Docosahexaenoic Acid Dimer (All-Z Isomer) Docosahexaenoic Acid (All-Z Isomer) Acids Docosahexaenoic Docosahexaenoic Acids Acids Docosahexenoic Docosahexenoic Acids Docosahexaenoic Acid Docosahexaenoate 10007848
Product Overview:
Resolvin D2-d5 (RvD2-d5) is intended for use as an internal standard for the quantification of resolvin D2 (Item No. 10007279) by GC- or LC-MS. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).{13989} In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.{14973} Resolvin D2 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation.{18209} It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM.{18209} Also, by stimulating nitric oxide production, resolvin D2 dose dependently decreases leukocyte-endothelial interactions. In a murine model of sepsis, resolvin D2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance.{18209}
Size 10 µg
Shipping dry ice
CAS Number 1881277-33-3
Molecular Formula C22H27D5O5
SMILES [2H]C([2H])(C([2H])([2H])[2H])/C=C\C[C@H](O)[C@H](O)/C=C/C=C/C=C\C=C\[C@@H](O)C/C=C\CCC(O)=O
Molecular Weight 381,5
Formulation A solution in ethanol
Purity ≥99% deuterated forms (d1-d5)
Custom Code 2916.19
UNSPSC code 12352100

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