Resolvin D2-d5

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Resolvin D2-d₅

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Cat No: 11184

Biochemicals - Isotopically Labeled Standards

Resolvin D2-d5 (RvD2-d5) is intended for use as an internal standard for the quantification of resolvin D2 (Item No. 10007279) by GC- or LC-MS. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahe...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

7S,16R,17S-trihydroxy-4Z,8E,10Z,12E,14E,19Z-21,21’,22,22,22-d5 docosahexaenoic acid

Correlated keywords:

LC-MS LC/MS GC-MS GC/MS mass spectrometry MS deuterateds deuteriums EPA DHA inflammation anti-inflammatory antiinflammatory immune responses sepsis Docosahexaenoic Acid 4,7,10,13,16,19-(Z,Z,Z,Z,Z,E-Isomer) Docosahexaenoic Acid 4,7,10,13,16,19-(All-Z-Isomer) Docosahexaenoic Acid 4,7,10,13,16,19-Isomer Docosahexaenoic Acid 3,6,9,12,15,18-Isomer Docosahexaenoic Acid Dimer (All-Z Isomer) Docosahexaenoic Acid (All-Z Isomer) Acids Docosahexaenoic Docosahexaenoic Acids Acids Docosahexenoic Docosahexenoic Acids Docosahexaenoic Acid Docosahexaenoate 10007848

Product Overview:
Resolvin D2-d5 (RvD2-d5) is intended for use as an internal standard for the quantification of resolvin D2 (Item No. 10007279) by GC- or LC-MS. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).{13989} In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.{14973} Resolvin D2 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation.{18209} It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM.{18209} Also, by stimulating nitric oxide production, resolvin D2 dose dependently decreases leukocyte-endothelial interactions. In a murine model of sepsis, resolvin D2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance.{18209}

Size	10 µg
Shipping	dry ice
CAS Number	1881277-33-3
Molecular Formula	C₂₂H₂₇D₅O₅
SMILES	[2H]C([2H])(C([2H])([2H])[2H])/C=C\C[C@H](O)[C@H](O)/C=C/C=C/C=C\C=C\[C@@H](O)C/C=C\CCC(O)=O
Molecular Weight	381,5
Formulation	A solution in ethanol
Purity	≥99% deuterated forms (d1-d5)
Custom Code	2916.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.