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Resolvin D1-d5

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    Resolvin D1-<wbr/>d<sub>5</sub>
  • Resolvin D1-<wbr/>d<sub>5</sub>
Cat No: 11182
Biochemicals - Isotopically Labeled Standards

Resolvin D1-d5 (RvD1-d5) is intended for use as an internal standard for the quantification of RvD1 (Item No. 10012554) by GC- or LC-mass spectrometry. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; Ite...


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Territorial Availability: Available through Bertin Technologies only in France
  • 7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-21,21',22,22,22-d5 docosahexaenoic acid
Correlated keywords:
  • EPA DHA inflammation antiinflammatory anti-inflammatory immune responses aspirin LOX peritonitis LOS neurochemistry resolvins 10007848 deuterateds deuteriums internal quantifies quantify quantification GC-MS GC/MS gases chromatography masses spectrometry LC-MS LC/MS liquids isotopes
Product Overview:
Resolvin D1-d5 (RvD1-d5) is intended for use as an internal standard for the quantification of RvD1 (Item No. 10012554) by GC- or LC-mass spectrometry. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310).{13989} In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.{14973} RvD1 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.{13989} A 17(R)-epimer of RvD1 can also be generated in aspirin-treated samples.{11433} Both RvD1 and its 17(R) configuration reduce human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of ~30 nM.{15718} RvD1 and its aspirin-triggered form also exhibit a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with a maximal inhibition of ~35% at a 10-100 ng dose.{15718}
Size 10 µg
Shipping dry ice
CAS Number 1881277-32-2
Molecular Formula C22H27D5O5
SMILES O[C@@H](C/C=C\C([2H])([2H])C([2H])([2H])[2H])/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)C/C=C\CCC(O)=O
Molecular Weight 381,5
Formulation A solution in ethanol
Purity ≥99% deuterated forms (d1-d5)
Custom Code 3822.19
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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