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DPY-30 (human recombinant)

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    DPY-<wbr/>30 (human recombinant)
  • DPY-<wbr/>30 (human recombinant)
Cat No: 11178
Proteins - More Proteins
Cayman

DPY-30 is a component of the MLL1 methylation complex, which interacts directly with Ash2L.{20265} In C. elegans, DPY-30 is required for dosage compensation in XX individuals, and its deletion or mutation is lethal. For XO individuals, DPY-30 is requi...

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: 50 µg

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Territorial Availability: Available through Bertin Technologies only in France
Correlated keywords:
  • epigenetics methyltransferase histones H3K4 genes regulations MLL proteins subunits Ash2L MLL sore complex DPY30 methylation C. elegans XX mutations XO growth development homodimer monomers WDR5 WDR-5 WDR 5 RbBP5 basal rates DPY-30L DPY30L hDPY30 SAF-19
Product Overview:
DPY-30 is a component of the MLL1 methylation complex, which interacts directly with Ash2L.{20265} In C. elegans, DPY-30 is required for dosage compensation in XX individuals, and its deletion or mutation is lethal. For XO individuals, DPY-30 is required for proper growth and development.{20266,20267} DPY-30 is a homodimer in solution, and two monomers interact with one Ash2L monomer.{20268} Addition of DPY-30 to the MLL1, WDR5, RbBP5, and Ash2L complex results in a 2-fold increase in methylation rate, from 300x the MLL1 basal rate to 600x the MLL1 basal rate.{20269}
Size 50 µg
Shipping dry ice
Formulation 50 mM Tris, pH 8.0, 100 mM sodium chloride, and 20% glycerol
Purity ≥95%
Custom Code 3504.00
UNSPSC code 12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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