Exendin-4 (48-86) amide (acetate

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Exendin-4 (48-86) amide (acetate)

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Cat No: 11096

Biochemicals - Receptor Pharmacology

Exendin-4 is a potent peptide agonist of the glucagon-like peptide 1 (GLP-1) receptor (Ki = 136 pM).{27501,27502,27504,24256} By activating the GLP-1 receptor, it stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expre...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

141732-?76-?5 286014-?72-?0 335149-?21-?8 141758-74-9 Exendin4 GLP1R T2D Heloderma suspectum

Product Overview:
Exendin-4 is a potent peptide agonist of the glucagon-like peptide 1 (GLP-1) receptor (Ki = 136 pM).{27501,27502,27504,24256} By activating the GLP-1 receptor, it stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma βTC-1 cells, supporting efficacy in type 2 diabetes.{27502} Exendin-4 was first isolated from the venom of H. horridum and consequently synthesized, with the recombinant peptide referred to as ‘exenatide.’ Exenatide protects hippocampal neurons against glutamate-induced apoptosis, suggesting utility in neuropathies associated with type 2 diabetes and in neurodegenerative diseases.{27503,27506} Exenatide also has anxiolytic and anti-depressant effects and induces satiety.{27506,27505}

Size	500 µg
Shipping	dry ice
CAS Number	914454-01-6
Molecular Formula	C₁₈₄H₂₈₂N₅₀O₆₀S • C₂H₄O₂
SMILES	NC([C@H](CO)NC([C@@H]1CCCN1C([C@@H]2CCCN2C([C@@H]3CCCN3C([C@@H](NC(CNC([C@H](CO)NC([C@H](CO)NC([C@@H]4CCCN4C(CNC(CNC([C@H](CC(N)=O)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@@]([C@H](CC)C)([H])NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCNC
Molecular Weight	4246,6
Formulation	A crystalline solid
Purity	≥95%
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.