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Fumitremorgin C

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    Fumitremorgin C
  • Fumitremorgin C
Cat No: 11030
Biochemicals - Transporter & Exchanger Modulators
Cayman
€285.00
Price is excluding VAT and does not include packaging neither shipping

Fumitremorgin C is a specific inhibitor of breast cancer resistance protein (BCRP/ABCG2) multidrug efflux transporter. At 5 μM, it significantly potentiates the toxicity of the chemotherapeutic drugs mitoxantrone, doxorubicin, and topotecan in S1-M1-3...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Pharma only in Europe
Synonyms:
  • 1,2,3,5aS,6,11,12S,14aS-octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione
Correlated keywords:
  • 12α-fumitremorgin C cancers multidrug resistance transporters inhibitors inhibition inhibits efflux toxicity breasts proteins BCRP/ABCG2 mitoxantrone doxorubicin topotecan S1-M1-3.2 colon carcinoma cells ABCB1 MRP1 ABCC1 P-glycoproteins fumitremorgin-C
Product Overview:
Fumitremorgin C is a specific inhibitor of breast cancer resistance protein (BCRP/ABCG2) multidrug efflux transporter. At 5 μM, it significantly potentiates the toxicity of the chemotherapeutic drugs mitoxantrone, doxorubicin, and topotecan in S1-M1-3.2 colon carcinoma cells.{20755} Fumitremorgin C reverses multidrug resistance in cells overexpressing BCRP but not P-glycoprotein (ABCB1) or MRP1 (ABCC1).{20754,20756}
Size 250 µg
Shipping wet ice
Stability Store at 4 degrees; shelf life 365 days
CAS Number 118974-02-0
Molecular Formula C22H25N3O3
SMILES C/C(C)=C/[C@@H]1N2[C@]([H])(C(N(CCC3)[C@]3([H])C2=O)=O)CC4=C1NC5=CC(OC)=CC=C54
Molecular Weight 379,5
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.59
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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Cross selling for this product : Fumitremorgin C There are 4 products.

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