Phthalazinone pyrazole

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Cat No: 10735

Biochemicals - Kinase Inhibitors

Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis.{19817} Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors.{19818} Phthalazinon...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-1(2H)-phthalazinone

Correlated keywords:

inhibitors inhibits inhibition auroras kinases cells cycle cancers centrosomes mitosis spindles cancers proliferation cells growth phosphorylation Auroroa-A Aurora-B Aurora-C A B C HCT116 HCT-116 Colo 116 HCT 116 Colo116 Colo-116 MCF7 MCF-7 MCF 7

Product Overview:
Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis.{19817} Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors.{19818} Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC50 = 31 nM).{19005} It does not inhibit Aurora B kinase at doses up to 100 μM.{19005} Phthalazinone pyrazole inhibits the proliferation of HCT116, COLO 205, and MCF-7 cells (IC50 = 7.8, 2.9, and 1.6 μM, respectively).{19005}

Size	1 mg
Shipping	dry ice
CAS Number	880487-62-7
Molecular Formula	C₁₈H₁₅N₅O
SMILES	O=C1C2=C(C=CC=C2)C(NC3=NNC(C)=C3)=NN1C4=CC=CC=C4
Molecular Weight	317,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.