Tyrosine Hydroxylase (rat, denat

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Tyrosine Hydroxylase (rat, denatured) Polyclonal Antibody

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Cat No: 10604

Tyrosine hydroxylase (TH) catalyzes the conversion of tyrosine to L-DOPA, which is the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and epinephrine.{56214} It assembles into tetramers, with each monomer compri...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

LDOPA Dystonia 14 DYT14 EC 1.14.16.2 OTTHUMP00000011225 OTTHUMP00000011226 ple Protein Pale TY3H

Product Overview:
Tyrosine hydroxylase (TH) catalyzes the conversion of tyrosine to L-DOPA, which is the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and epinephrine.{56214} It assembles into tetramers, with each monomer comprised of an N-terminal regulatory domain with three serine residues at positions 19, 31, and 40 that are subject to regulatory phosphorylation, a central catalytic domain, and a C-terminal tetramerization domain. TH is expressed in dopaminergic neurons in the olfactory bulb, diencephalon, substantia nigra, ventral tegmental area, and retinal amacrine cells, adrenergic and noradrenergic cells in the hypothalamus, medulla, and locus coeruleus (LC), as well as sympathetic ganglia and adrenal chromaffin cells. Due to its expression in catecholaminergic neurons, TH has been used as a marker of these cells in the brain.{56215} Mutations in TH have been found in patients with tyrosine hydroxylase deficiency, infantile parkinsonism, and progressive infantile encephalopathy.{56216,56217} Cayman's Tyrosine Hydroxylase (rat, denatured) Polyclonal Antibody can be used for immunocytochemistry (ICC), immunohistochemistry (IHC), and Western Blot (WB) applications. The antibody recognizes TH at approximately 60 kDa from mammalian samples.

Size	1 ea
Shipping	dry ice
Host	Rabbit
Antigen	SDS-denatured rat tyrosine hydroxylase, purified from pheochromocytoma
Application(s)	ICC, IHC, WB
Formulation	100 µl of Affinity-purified polyclonal antibody
Custom Code	3822.19
UNSPSC code	12352203

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.