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ABC294640

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    ABC294640
  • ABC294640
Cat No: 10587
Biochemicals - Kinase Inhibitors
Cayman
€46.00
Price is excluding VAT and does not include packaging neither shipping

ABC294640 is a selective inhibitor of sphingosine kinase 2 (SPHK2; Ki = 9.8 μM).{18506} It inhibits SPHK2 in a dose-dependent manner (IC50 = 60 μM) without affecting SPHK1 activity at concentrations up to 100 μM. ABC294640 is inactive against a panel ...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Pharma only in Europe
Synonyms:
  • 3-(4-chlorophenyl)-N-(4-pyridinylmethyl)-tricyclo[3.3.1.13,7]decane-1-carboxamide
Correlated keywords:
  • ABC-294640 SPHK-2 1 MDAMB231 HT29 A498 opaganib 3H-S1P IBD
Product Overview:
ABC294640 is a selective inhibitor of sphingosine kinase 2 (SPHK2; Ki = 9.8 μM).{18506} It inhibits SPHK2 in a dose-dependent manner (IC50 = 60 μM) without affecting SPHK1 activity at concentrations up to 100 μM. ABC294640 is inactive against a panel of 20 lipid-regulated kinases at a concentration of 50 μM. It decreases [3H]sphingosine 1 phosphate ([3H]S1P) production in MDA-MB-231 cells in a dose-dependent manner. ABC294640 inhibits proliferation of human tumor cell lines with IC50 values ranging from 6 to 48 μM with HepG2 and HT-29 cells being the most and least sensitive, respectively. In a scratch assay, ABC294640 reduces A-498 cell migration via reduction of actin filament polymerization. In vivo, ABC294640 reduces growth of mammary adenocarcinoma xenografts in mice in a dose-dependent manner. It also attenuates progression of inflammatory bowel disease induced by trinitrobenzene sulfonic acid (TNBS) in mice and rats.{37136}
Size 1 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 915385-81-8
Molecular Formula C23H25ClN2O
SMILES O=C(NCC1=CC=NC=C1)[C@]23C[C@](C[C@H](C4)C3)(C5=CC=C(Cl)C=C5)C[C@@H]4C2
Molecular Weight 380,9
Formulation A crystalline solid
Purity ≥98%
Custom Code 2903.99
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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Cross selling for this product : ABC294640 There are 2 products.

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