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  • ABC294640
Cat No: 10587
Biochemicals - Kinase Inhibitors

ABC294640 is an inhibitor of sphingosine kinase 2 (SPHK2; Ki = 9.8 μM).{18506} It inhibits SPHK2 (IC50 = 60 μM) without affecting SPHK1 activity up to 100 μM but does reduce SPHK1 isoform a (SPHK1a) protein levels in androgen-independent LNCaP (LNCaP-...


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Territorial Availability: Available through Bertin Technologies only in France
  • 3-(4-chlorophenyl)-N-(4-pyridinylmethyl)-tricyclo[,7]decane-1-carboxamide
Correlated keywords:
  • ABC-294640 SPHK-2 1 1a MDAMB231 HT29 A498 opaganib 3H-S1P IBD LNCapAI Hep G2 PANC1
Product Overview:
ABC294640 is an inhibitor of sphingosine kinase 2 (SPHK2; Ki = 9.8 μM).{18506} It inhibits SPHK2 (IC50 = 60 μM) without affecting SPHK1 activity up to 100 μM but does reduce SPHK1 isoform a (SPHK1a) protein levels in androgen-independent LNCaP (LNCaP-AI) cells via an SPHK1-indirect, proteasomal-dependent mechanism when used at concentrations ranging from 5 to 25 µM.{56206} ABC294640 is inactive against a panel of 20 lipid-regulated kinases at 50 μM.{18506} It decreases sphingosine-1-phosphate (S1P) production in MDA-MB-231 cells in a concentration-dependent manner. ABC294640 inhibits proliferation of a variety of cancer cells, including HepG2 liver, A-498 kidney, PANC-1 pancreas, and HT-29 colon cells (IC50s = 6, 12.2, 32.8, and 48.1 µM, respectively). It reduces actin filament polymerization in, and cell migration of, A-498 cells in a scratch assay. Oral administration of ABC294640 (35 and 100 mg/kg every other day) reduces tumor growth in a mouse syngeneic model of mammary adenocarcinoma. It also reduces colonic inflammation in mouse and rat models of Crohn’s disease induced by trinitrobenzene sulfonic acid (TNBS).{37136}
Size 1 mg
Shipping dry ice
CAS Number 915385-81-8
Molecular Formula C23H25ClN2O
SMILES O=C(NCC1=CC=NC=C1)[C@]23C[C@](C[C@H](C4)C3)(C5=CC=C(Cl)C=C5)C[C@@H]4C2
Molecular Weight 380,9
Formulation A crystalline solid
Purity ≥98%
Custom Code 2903.99
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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